Phase 2
N=62
D1 and D2 Dopamine Receptors in Gambling and Amphetamine Reinforcement
Pathological Gambling
Bottom Line
View on ClinicalTrials.gov: NCT02203786 ↗Enrolled (actual)
62
Serious AEs
0.0%
Results posted
Apr 2016
Primary outcome: Primary: Subjective Reinforcement Self-report Scales — 4.8; 4.8; 9.5; 9.3 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Haloperidol (Drug); Fluphenazine (Drug); Dexedrine (Drug); Placebo (Drug); Slot Machine (Behavioral)
- Age
- Adult, Older Adult · 19+ yrs
- Sex
- All
- Sponsor
- Centre for Addiction and Mental Health
- Primary completion
- Jun 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Subjective Reinforcement Self-report Scales |
4.8; 4.8; 9.5; 9.3; 4.2; 4.8 | — |
| SECONDARY Diastolic Blood Pressure (DBP) |
20.2; 22; 15.1; 23.6; 22.5; 21.6 | — |
| SECONDARY Cognitive Task Performance |
91.6; 94.0; 94.8; 91.0; 95.5; 98.1 | — |
| SECONDARY Betting Behaviour in Laboratory-based Slot Machine Game |
12.8; 16.0; 11.6; 14.4; 10.4; 16.1 | — |
| SECONDARY Speed of Play on Slot Machine Game |
76.9; 78.5; 66.4; 71.8; 88.6; 68.4 | — |
| SECONDARY Winnings on Slot Machine Upon Completion of Game |
239; 277.8; 449.1; 544.3; 562.4; 140.8 | — |
Summary
To determine if:
1. pathological gambling is similar to psychostimulant addiction as reflected by parallel roles for D1 and D2 receptors in gambling and stimulant reinforcement.
2. these parallel roles are linked with gambling pathology or if they are evident in both gamblers and controls.
Eligibility Criteria
Inclusion Criteria
- PATHOLOGICAL GAMBLERS
- otherwise healthy, non-treatment seeking, non-abstinent
- male or female
- ages 19-65
- DSM-IV PG symptom scale score > 5
- SOGS (South Oaks Gambling Screen) score > 5
- nicotine dependence acceptable
- CONTROLS
- healthy
- male or female
- ages 19-65
- DSM-IV PG symptom scale score = 0
- SOGS score = 0
- nicotine dependence acceptable
- must have played slot machine > 5 times
Exclusion Criteria
- both Pathological Gamblers and Controls
- Axis I psychopathology aside from nicotine dependence (or PG) based on SCID
- Schizotypal or Borderline Personality Disorder based on psychiatric interview
- Family history of schizophrenia or bipolar disorder
- English comprehension below grade 7 level.
- ADS (Alcohol Dependence Scale) > 13 (more than low dependence)
- BDI (Beck Depression Inventory) short form > 10 (more than low depression)
- DAST (Drug Abuse Screening Test) > 4 (possible drug abuse)
- Consumption of > 20/15 (men/women) standard alcoholic drinks/ week (hazardous drinking)
- Smoking > 20 cigarettes/day to help minimize withdrawal symptoms during test phase
- Any prior use of psychostimulant drugs
- Current use of medication that could interact with any of the study medications
- Women who are pregnant or breastfeeding
Data sourced from ClinicalTrials.gov (NCT02203786). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.