N/A N=21 Randomized Treatment

Improving Memory Performance by Applying Cognitive Training

HIV

Bottom Line

View on ClinicalTrials.gov: NCT02216591 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2017

Primary outcome: Primary: Change in Working Memory — 51.33; 43.15 mean T score on working memory tests — p=.013

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Active Cognitive Training (ACT) (Device); Control (CON) (Device)
Age: Adult · 18+ yrs
Sex: All
Sponsor: Duke University
Primary completion: Jun 2016

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Working Memory	51.33; 43.15	.013 sig
SECONDARY Change in Delay Discounting	8.62; 8.81	.274

Summary

The proposed study will test the efficacy of a cognitive training program to improve working memory in a sample of HIV-infected persons. Investigators will assign 40 HIV-infected adults with poor medication adherence to one of two conditions (20/group): the experimental cognitive training intervention or a control training condition. Participants will complete 12 training sessions across 10 weeks and will complete assessments at baseline and post-training. The specific aims are to: 1. Investigate the effects of the cognitive training intervention on working memory and delay discounting in HIV-infected persons. Hypothesis 1: Participants assigned to active cognitive training, compared to those in the attention-matched control group, will have greater improvements in working memory and reductions in delay discounting. 2. Characterize adherence to antiretroviral medications in this population and examine medication adherence after cognitive training. Hypothesis 2: Participants assigned to active cognitive training, compared to those in the attention-matched control group, will have greater improvements in medication adherence.

Eligibility Criteria

Inclusion Criteria

HIV infection, diagnosed for > 6 months
Currently on treatment with antiretroviral medications for > 3 months
Self-reported medication adherence at less than 90%
Lives within 15 miles of the research site in stable housing and with no plans to move from the area in the next 3 months

Exclusion Criteria

Current substance use disorder
Any drug use other than alcohol or marijuana in the past year
Pregnancy
English non-fluency or illiteracy
≤ 8th grade education
serious neurological disorders, including HIV dementia
traumatic brain injury
severe mental illness or acute psychiatric distress
impaired mental status

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02216591). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.