N/A
N=64,882
Epidemiology of Acute Kidney Injury in England - 1998 to 2013
Acute Kidney Injury
Bottom Line
View on ClinicalTrials.gov: NCT02216695 ↗Enrolled (actual)
64,882
Serious AEs
—
Results posted
Dec 2016
Primary outcome: Primary: Secular Trends in the Mortality After Acute Kidney Injury From 1998 to 2013 — 1296; 3763; 19793 participants
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Pediatric, Adult, Older Adult · 0+ yrs
- Sex
- All
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
- Primary completion
- Dec 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Secular Trends in the Mortality After Acute Kidney Injury From 1998 to 2013 |
1296; 3763; 19793 | — |
| PRIMARY Incidence of AKI-D From 1998-9 to 2012-13 |
774; 807; 793; 914; 980; 1172 | — |
| SECONDARY Mortality From Acute Kidney Injury in Each Age Group From 1998 to 2013 |
8271; 7030; 7959; 1592 | — |
| SECONDARY Mortality From Acute Kidney Injury in Each Five-year Period From 1998 to 2013 |
1296; 3763; 19793 | — |
Summary
The true population incidence of acute kidney injury (AKI), previously called acute renal failure, in England is not known. A better understanding of the epidemiology of AKI at a national level is essential to inform initiatives to prevent AKI as well as reduce the associated morbidity and mortality. The purpose of this study is to combine the national database of all hospital discharges with national census data to investigate trends in the incidence of both, AKI not requiring dialysis and AKI requiring dialysis, as well as its associated mortality and its determinants in England between 1998 and 2013
Eligibility Criteria
Inclusion Criteria
- Patients with any of the following ICD 10 codes, in any of the diagnoses, in the HES database, will be included: N17.0 for acute renal failure with tubular necrosis, N17.1 for acute renal failure with acute cortical necrosis, N17.2 for acute renal failure with medullary necrosis, N17.8 for other acute renal failure and N17.9 for acute renal failure, unspecified.
- All patients of any age and gender, with AKI as identified as above between the period of 1st April 1998 and 31st March 2013.
Exclusion Criteria
- Patients with any of the following codes in any of the diagnoses codes will be excluded: N18.5 for chronic kidney disease stage 5, N18.6 for end stage renal disease.
- Patients with following codes in the any of the procedure codes will be excluded: L74.2 for arterio-venous fistula, L74.3 for arterio-venous graft.
- Patients', who were admitted in the study period, but were not discharged, will be excluded.
Data sourced from ClinicalTrials.gov (NCT02216695). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.