N/A N=51 Diagnostic

The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers

Prediabetes

Bottom Line

View on ClinicalTrials.gov: NCT02229487 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2017

Primary outcome: Primary: GLP-1 Levels in Response to Oral Glucose Tolerance Test — 16.66; 18.57 pmol/l.h — p=0.209

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Oral glucose tolerance (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Ramathibodi Hospital
Primary completion: Mar 2017

Outcome Measures

Outcome	Result	p-value
PRIMARY GLP-1 Levels in Response to Oral Glucose Tolerance Test	16.66; 18.57	0.209

Summary

Hypothesis 1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration. 2. Prediabetes patients with short sleep will have a delayed or reduced GLP-1 response to a standardized meal

Eligibility Criteria

Inclusion Criteria

Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital
Age 18 or older
Can understand Thai (speaking, listening and reading)
Agree to participate by written informed consent

Exclusion Criteria

Those who depend on others for feeding (such as stroke patients)
Shift workers
History of congestive heart failure or low ejection fraction
Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT > 3 times the upper limit of normal)
Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin
Patients with permanent pacemaker
History of previous stroke

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02229487). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.