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Diabetes & Endocrinology
Meta-analysis
SMS Text Messaging Lifestyle Programs Show No Significant Benefit for Prediabetes
SMS lifestyle programs show no clear benefit for prediabetes outcomes in this meta-analysis
This systematic review and meta-analysis of 4632 adults with prediabetes found that SMS text messaging-delivered lifestyle programs did not …
A large review of text message health programs found no significant improvement in weight or diabetes risk for adults with prediabetes.
May 1, 2026
Diabetes & Endocrinology
Meta-analysis
Reversion of Prediabetes to Normoglycemia Linked to 68% Lower Diabetes Risk
Reversing prediabetes cuts diabetes risk by 68 percent in a massive study
A meta-analysis of 535,066 participants with prediabetes found that reversion to normoglycemia was associated with a 68% lower risk of incid…
Reversing prediabetes to normal blood sugar levels lowers the risk of developing diabetes by 68 percent in people with the condition.
May 1, 2026
Geriatrics & Aging
Cohort
Prediabetes Associated With Higher Incidence of Frailty and Functional Deficits in Adults Aged 50 Years or Older
Prediabetes Linked to Higher Frailty Risk in Older Adults
This cohort study analyzed 18,571 adults aged 50 years or older across five longitudinal aging cohorts. Baseline prediabetes was associated …
In a large study of over 18,000 older adults, prediabetes was associated with higher rates of frailty and functional decline compared to nor…
medRxiv
Apr 24, 2026
Diabetes & Endocrinology
Cohort
Qualitative Study Examines Diet Management Experiences in Swedish Women With Prediabetes
Diet management creates emotional tension for women with prediabetes
This qualitative study within the SCAPIS cohort explores diet management experiences among 16 Swedish women aged 59–72 with prediabetes. Par…
Women aged 59 to 72 with prediabetes describe how managing diet creates emotional tension between health goals and food comfort.
Frontiers
Apr 22, 2026
Diabetes & Endocrinology
Cohort
Untargeted LC-MS/MS profiling identifies metabolite networks associated with glycemic dysregulation in diabetes cohorts.
A new chemical link connects early diabetes risks to specific proteins in your blood.
This cohort study profiled 15,470 serum metabolite features in people with normal glucose tolerance, prediabetes, and type 2 diabetes. Coreg…
Scientists found a specific chemical pattern that grows stronger as diabetes gets worse, offering a fresh view on how the disease starts.
medRxiv
Apr 21, 2026
Diabetes & Endocrinology
RCT
Anakinra reduces inflammatory markers in prediabetes but shows no metabolic improvements in RCT
Two anakinra injections changed blood markers in people with prediabetes
A randomized controlled trial in individuals with prediabetes found that two injections of anakinra significantly reduced total leucocyte co…
Two anakinra injections quickly lowered inflammation markers in people with prediabetes, though the drug did not yet improve blood sugar con…
Apr 14, 2026
Nutrition & Obesity Medicine
RCT
Feijoa powder supplementation did not improve weight or glucose but lowered systolic blood pressure in adults with prediabetes.
Feijoa Powder Helps Lower Blood Pressure
This 6-month randomized controlled trial enrolled 97 adults with overweight and prediabetes. Participants received either 1.15 g/day of whol…
Adding feijoa powder to a diet helped lower blood pressure and keep weight off after a weight-loss program ended.
medRxiv
Apr 14, 2026
Diabetes & Endocrinology
Cohort
PIEZO1 variant rs563555492T associated with lower HbA1c and reduced prediabetes risk in South Asian cohorts.
A Hidden Gene Is Masking Diabetes in South Asians
This observational cohort study examined 62,909 South Asians from India and the UK to assess the impact of the PIEZO1 rs563555492T variant. …
A gene common in South Asians can make standard diabetes blood tests look normal even when blood sugar is high, hiding the disease for years…
medRxiv
Apr 14, 2026
Nutrition & Obesity Medicine
Later eating start time associated with worse glycaemic parameters and higher body fat in prediabetes.
Does eating later in the day raise your insulin levels and body fat?
This observational review examined 297 individuals with prediabetes to assess the impact of eating start time on metabolic health. Results i…
Delaying your first meal by an hour raises fasting insulin and total body fat in adults with prediabetes, suggesting earlier eating may help…
medRxiv
Apr 14, 2026
Diabetes & Endocrinology
Cohort
Lower creatinine-to-body weight ratio associated with increased prediabetes risk in Chinese adults
Study links lower creatinine-to-weight ratio with higher prediabetes risk in Chinese adults
A retrospective cohort study of 173,476 Chinese adults from health check-up programs found that a lower baseline creatinine-to-body weight r…
A lower creatinine-to-weight ratio found in routine blood tests is linked to a higher risk of developing prediabetes in Chinese adults.
Frontiers
Apr 7, 2026
Diabetes & Endocrinology
Prediabetes in youth with overweight/obesity associated with lower baseline cognition, stable over 2 years
Could prediabetes affect how young people with obesity think and learn?
A 2-year longitudinal observational study of 67 youth with overweight/obesity found those with prediabetes had lower IQ and poorer executive…
Youth with prediabetes show lower IQ and slower thinking skills compared to peers with normal blood sugar, and these cognitive differences s…
medRxiv
Apr 5, 2026
Diabetes & Endocrinology
Cohort
Horseshoe-like plantar hyperkeratosis associated with prediabetes in overweight adults
Could a specific foot skin change be a visible clue for prediabetes?
A cross-sectional cohort study of 191 adults with overweight or obesity found horseshoe-like plantar hyperkeratosis (HSLPH) was more frequen…
A horseshoe-shaped patch of thickened skin on the foot is a strong visual clue for prediabetes in adults with overweight or obesity.
Frontiers
Apr 4, 2026