Metformin is associated with higher lactate concentrations during exercise in adults with prediabetes and type 2 diabetes
Metformin May Raise Lactate During Exercise
This meta-analysis of 325 participants evaluated the impact of metformin on exercise metabolism and capacity. The analysis found that metfor…
A new analysis suggests metformin may increase lactate levels during exercise, which could affect workout intensity.
Semaglutide Improves Metabolic Health in Schizophrenia Patients on Antipsychotics
Semaglutide improves blood sugar and weight in people with schizophrenia and prediabetes
A randomized, placebo-controlled trial in 154 overweight or obese individuals with schizophrenia and prediabetes receiving second-generation…
A new trial shows semaglutide helps lower blood sugar and reduce weight in people with schizophrenia who also have prediabetes or obesity.
Metabolic subtypes identify Japanese adults with prediabetes at highest or lowest T2D risk
Japanese adults with prediabetes benefit most from lifestyle changes in one specific metabolic group
This randomized controlled trial enrolled 295 Japanese adults with impaired glucose tolerance in the Japanese Diabetes Prevention Program. P…
A study of 295 Japanese adults found that lifestyle changes work best for those with a specific metabolic pattern. This group had the lowest…
Tirzepatide improves waist-to-height ratio in adults with obesity or overweight
Tirzepatide improves waist-to-height ratio in obesity and prediabetes
A post-hoc analysis of a Phase 3 RCT found that tirzepatide (10/15 mg) improved waist-to-height ratio (WHtR) in adults with obesity or overw…
A new analysis finds tirzepatide helps more people with obesity achieve a healthier waist-to-height ratio, a key measure of belly fat risk.
SMS Text Messaging Lifestyle Programs Show No Significant Benefit for Prediabetes
SMS lifestyle programs show no clear benefit for prediabetes outcomes in this meta-analysis
This systematic review and meta-analysis of 4632 adults with prediabetes found that SMS text messaging-delivered lifestyle programs did not …
A large review of text message health programs found no significant improvement in weight or diabetes risk for adults with prediabetes.
Reversion of Prediabetes to Normoglycemia Linked to 68% Lower Diabetes Risk
Reversing prediabetes cuts diabetes risk by 68 percent in a massive study
A meta-analysis of 535,066 participants with prediabetes found that reversion to normoglycemia was associated with a 68% lower risk of incid…
Reversing prediabetes to normal blood sugar levels lowers the risk of developing diabetes by 68 percent in people with the condition.
Semaglutide improves physical quality of life in schizophrenia with prediabetes
Semaglutide improves physical quality of life in adults with schizophrenia and obesity
This secondary analysis of a randomized trial in 154 adults with schizophrenia, prediabetes, and overweight or obesity found that once-weekl…
A secondary analysis of a trial found that once-weekly semaglutide improved physical quality of life in adults with schizophrenia and obesit…
Lifestyle intervention linked to sustained prediabetes remission in 12% of adults
Three years of lifestyle changes helped 12% of people with prediabetes achieve sustained remission
This post-hoc analysis of an RCT included 846 adults with prediabetes and overweight/obesity.
A three-year lifestyle plan helped 12% of adults with prediabetes and overweight reach sustained remission, showing that maintaining weight …
Prediabetes Associated With Higher Incidence of Frailty and Functional Deficits in Adults Aged 50 Years or Older
Prediabetes Linked to Higher Frailty Risk in Older Adults
This cohort study analyzed 18,571 adults aged 50 years or older across five longitudinal aging cohorts.
In a large study of over 18,000 older adults, prediabetes was associated with higher rates of frailty and functional decline compared to nor…
Qualitative Study Examines Diet Management Experiences in Swedish Women With Prediabetes
Diet management creates emotional tension for women with prediabetes
This qualitative study within the SCAPIS cohort explores diet management experiences among 16 Swedish women aged 59–72 with prediabetes.
Women aged 59 to 72 with prediabetes describe how managing diet creates emotional tension between health goals and food comfort.
Untargeted LC-MS/MS profiling identifies metabolite networks associated with glycemic dysregulation in diabetes cohorts
A new chemical link connects early diabetes risks to specific proteins in your blood
This cohort study profiled 15,470 serum metabolite features in people with normal glucose tolerance, prediabetes, and type 2 diabetes.
Scientists found a specific chemical pattern that grows stronger as diabetes gets worse, offering a fresh view on how the disease starts.
Anakinra reduces inflammatory markers in prediabetes but shows no metabolic improvements in RCT
Two anakinra injections changed blood markers in people with prediabetes
A randomized controlled trial in individuals with prediabetes found that two injections of anakinra significantly reduced total leucocyte co…
Two anakinra injections quickly lowered inflammation markers in people with prediabetes, though the drug did not yet improve blood sugar con…
Questions about Prediabetes
What are the diet management experiences of Swedish women living with prediabetes?
Swedish women with prediabetes experience tension between health goals and emotional needs around food, feeling pressured to manage their own and their family's eating habits.
Full answer →Is prediabetes linked to higher risks of frailty in adults aged 50 or older?
Yes, prediabetes is linked to a higher risk of frailty and functional decline in adults aged 50 or older, according to a large pooled analysis of longitudinal studies.
Full answer →How much lower is the diabetes risk if prediabetes reverts to normal blood sugar?
Reversing prediabetes to normal blood sugar is linked to a 68% lower risk of developing type 2 diabetes, based on a large meta-analysis.
Full answer →Can lifestyle interventions lead to sustained remission of prediabetes in overweight adults?
Yes, lifestyle interventions can lead to sustained prediabetes remission in about 12% of overweight adults, with those achieving remission having a 68% lower risk of developing diabetes.
Full answer →Does semaglutide improve quality of life for adults with schizophrenia and prediabetes?
Yes, semaglutide improves physical quality of life in adults with schizophrenia and prediabetes, but not mental quality of life, based on a 30-week trial.
Full answer →All Prediabetes Articles
- Metformin is associated with higher lactate concentrations during exercise in adults with prediabetes and type 2 diabetes
- Semaglutide Improves Metabolic Health in Schizophrenia Patients on Antipsychotics
- Metabolic subtypes identify Japanese adults with prediabetes at highest or lowest T2D risk
- Tirzepatide improves waist-to-height ratio in adults with obesity or overweight
- Semaglutide improves physical quality of life in schizophrenia with prediabetes
- Lifestyle intervention linked to sustained prediabetes remission in 12% of adults
- Reversion of Prediabetes to Normoglycemia Linked to 68% Lower Diabetes Risk
- SMS Text Messaging Lifestyle Programs Show No Significant Benefit for Prediabetes
- Prediabetes Associated With Higher Incidence of Frailty and Functional Deficits in Adults Aged 50 Years or Older
- Qualitative Study Examines Diet Management Experiences in Swedish Women With Prediabetes
- Untargeted LC-MS/MS profiling identifies metabolite networks associated with glycemic dysregulation in diabetes cohorts
- Later eating start time associated with worse glycaemic parameters and higher body fat in prediabetes
- Feijoa powder supplementation did not improve weight or glucose but lowered systolic blood pressure in adults with prediabetes
- PIEZO1 variant rs563555492T associated with lower HbA1c and reduced prediabetes risk in South Asian cohorts
- Anakinra reduces inflammatory markers in prediabetes but shows no metabolic improvements in RCT
- Lower creatinine-to-body weight ratio associated with increased prediabetes risk in Chinese adults
- Prediabetes in youth with overweight/obesity associated with lower baseline cognition, stable over 2 years
- Higher HbA1c linked to reduced cortical thickness, gray matter in youth; effect stronger in deprived neighborhoods
- Horseshoe-like plantar hyperkeratosis associated with prediabetes in overweight adults
- Disseminated herpes zoster hospitalization linked to higher newly identified diabetes, prediabetes prevalence
- Meta-analysis finds BMI, but not waist circumference, associated with prediabetes risk