N/A
Completed N=2,472
Comparative Effectiveness of Antibiotics for Respiratory Infections
Acute otitis media · Acute Sinusitis · Group A streptococcal pharyngitis
Source: ClinicalTrials.gov NCT02297815 ↗
Enrolled (actual)
2,472
Serious AEs
0.0%
Results posted
Dec 2017
Primary outcomePrimary: Health Related Quality of Life Score — 91.5; 90.2 scores on a scale — p=0.008
Summary
The purpose of this study is to identify and use patient centered outcomes to compare narrow-spectrum and broad-spectrum antibiotics for the treatment of common acute respiratory tract infections (ARTIs) in children.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Health Related Quality of Life Score |
91.5; 90.2 | 0.008 sig |
| SECONDARY Missed School or Daycare From Illness |
503; 305 | 0.39 |
| SECONDARY Required Additional Childcare |
390; 220 | 0.59 |
| SECONDARY Experience Side Effects |
341; 258 | <0.001 sig |
| SECONDARY Symptoms Present on Day 3 |
427; 267 | 0.09 |
| SECONDARY Sleep Disturbance |
582; 378 | 0.07 |
Eligibility Criteria
Inclusion Criteria
We included children between six months and 12 years old, diagnosed with an ARTI (acute otitis media, acute sinusitis, Group A streptococcal [GAS] pharyngitis) using International Classification of Diseases diagnosis codes and prescribed an antibiotic. For GAS pharyngitis, the child also had a positive rapid streptococcal test.
Exclusion Criteria
- Diagnosed with multiple ARTIs
- Diagnosed with another non-ARTI bacterial infection
- Prescribe antibiotics in the past 30 days
- Non-English speaking families
- If GAS pharyngitis diagnosis, age < 3 years
Data sourced from ClinicalTrials.gov (NCT02297815). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.