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Home › Conditions › Acute otitis media

Acute otitis media

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Acute otitis media

22 trials tracked for Acute otitis media: 7 in phase 3 or 4 and 1 with published results. The most-cited published study has 30 citations.

22Trials tracked
7Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 5 Phase 2 5 Phase 1 1 Other / NA 9
  1. Phase 3 Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media Completed · 30 cited
  2. Phase 4 A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children Completed
  3. Phase 4 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed
  4. Phase 3 Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children Completed
  5. Phase 3 Evaluation of the Tympanostomy Tube Delivery System Completed
  6. Phase 3 Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients Completed
Show 16 more trials
  1. Phase 3 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients Completed
  2. Phase 2 Open-Label Study of OTO-201 for Treatment of AOMT Completed
  3. Phase 2 Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media Completed
  4. Phase 2 A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months Completed
  5. Phase 2 Pharmacokinetics Of Azithromycin Immediate Release And Extended Release Formulation In Kids With Acute Otitis Media Completed
  6. Phase 2 Dose Ranging Study of OTO-201 in AOMT Completed
  7. Phase 1 Evaluation of Safety and Reduction of Ear Pain in Adults With Acute Otitis Media and Reduction of Ear Pain in Adults With Acute Otitis Media Completed
  8. N/A Impact of Prevnar 13 on Ear Infections in Children Completed
  9. N/A Evaluation of Cellphone Based Otoscopy in Pediatric Patients Completed
  10. N/A Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media Completed
  11. N/A Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions Completed
  12. N/A Comparative Effectiveness of Antibiotics for Respiratory Infections Completed
  13. N/A Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto) Completed
  14. N/A Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus Completed
  15. N/A Ear Drops for Children With Otitis Media Completed
  16. N/A Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid Tonsil Completed

Showing the 22 most-cited and recently-updated of 22 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Probiotic strains CBA-L74 and SS-K12 significantly reduce acute otitis media incidence in children
Nutrition & Obesity Medicine Meta-analysis
Probiotic strains CBA-L74 and SS-K12 significantly reduce acute otitis media incidence in children Specific probiotic strains may lower risk of ear infections in children
This network meta-analysis of 18 RCTs involving 4,462 children found that probiotic strains CBA-L74 (OR 0.27) and SS-K12 (OR 0.44) significa…
New research identifies specific probiotic strains that could help prevent middle ear infections and reduce antibiotic use in children.
Frontiers Jul 7, 2026
RSV infection complicated by acute otitis media in 27.7% of children under 5
Pediatrics Meta-analysis
RSV infection complicated by acute otitis media in 27.7% of children under 5 RSV infection often leads to middle ear infections in children
This meta-analysis of children aged 0-60 months found that 27.7% of RSV infections are complicated by acute otitis media (AOM), and RSV is d…
Nearly 28% of children with RSV infections develop a middle ear infection, which is often complicated by bacterial growth.
Jun 27, 2026