Hypofractionated Stereotactic Irradiation (HFSRT) With Pembrolizumab and Bevacizumab for Recurrent High Grade Gliomas

Inclusion Criteria

• Histologically confirmed diagnosis of World Health Organization (WHO) Grade III (except anaplastic oligodendroglioma) or IV malignant glioma.
• Documented recurrence by diagnostic biopsy or contrast enhanced magnetic resonance imaging (MRI) performed within 28 days of entry into the trial as per Response Assessment Criteria for High-Grade Gliomas (RANO) Criteria.
• Patients with recurrent WHO Grade III gliomas should have received one prior treatment for recurrent high grade disease.
• Maximum diameter of enhancing tumor (target lesion) should be ≤ 3.5 cm.
• Interval of ≥ 6 months after the end of prior radiation therapy is required unless there is a new recurrence outside of the previous radiotherapy treatment field.
• Previous first line treatment with at least standard dose of radiotherapy (total dose ≥ 54 Gy) and temozolomide.
• Interval of ≥ 4 weeks since surgical resection prior to entry into the trial.
• Interval of ≥ 4 weeks after last administration of any investigational agent or prior cytotoxic therapy (except bevacizumab). There should be 14 days interval between the last dose of bevacizumab and first day of treatment on study.
• Age 18 years or older on day of signing informed consent.
• Karnofsky performance status ≥ 70.
• Demonstrate adequate organ function.
• Resting baseline O2 saturation by pulse oximetry of ≥ 92% at rest.
• Must have recovered from the toxic effects of prior therapies.
• Willing and able to provide written informed consent/assent for the trial.
• Life expectancy ≥ 12 weeks.
• Female participants of childbearing potential should have a negative urine or serum pregnancy within 72 hours prior to receiving first dose of study medication. Must be willing to use 2 methods of birth control or be surgically sterile, or abstain from heterosexual activity for the course of the study through 120 days after the last dose of study medication.
• Male participants should agree to use an adequate method of contraception starting with the first dose of study therapy through 120 days after the last dose of study therapy.

Exclusion Criteria

• More than 3 recurrences of high grade glioma.
• Has anaplastic oligodendroglioma.
• Has received reradiation to recurrent disease (other than standard frontline adjuvant radiation therapy).
• Recurrent tumors near the brainstem and optic chiasm must not have received prior radiation therapy.
• Infratentorial, or leptomeningeal evidence of recurrent disease.
• Recurrent or persistent tumor (enhancing area) greater than 3.5 cm in maximum diameter.
• Prior treatment with Gliadel unless it was administered as first line treatment and ≥ 3 months prior to study treatment.
• Unable (due to existent medical condition) or unwilling to have a contrast enhanced MRI of brain.
• Currently participating in or has participated in a study of an investigational agent or using an investigational device within 4 weeks of first dose of treatment.
• Diagnosis of immunodeficiency or is receiving systemic immunosuppressive therapy within 7 days prior to the first dose of trial treatment. Physiologic doses of steroid therapy (≤ 10 mg/day prednisone equivalents) is allowed.
• Prior chemotherapy, targeted small molecule therapy, or monoclonal antibody (except bevacizumab) within 4 weeks prior to study Day 1 or has not recovered (i.e., ≤ Grade 1 or at baseline) from adverse events due to agents administered more than 4 weeks earlier. Wash out period for bevacizumab is 14 days.
• Known additional malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or in situ cervical cancer that has undergone potentially curative therapy.
• Active autoimmune disease requiring systemic treatment within past 3 months or documented history of clinically severe autoimmune disease, or syndrome that requires systemic steroids or immunosuppressive agents.
• Evidence of interstitial lung disease or ac