N/A
Completed N=169
Screening for Chronic Obstructive Pulmonary Disease in Patients With Acute Coronary Syndromes
Source: ClinicalTrials.gov NCT02324660 ↗Enrolled (actual)
169
Serious AEs
0.0%
Results posted
Aug 2017
Primary outcomePrimary: COPD Diagnosis — 39 participants
Summary
Several studies and registries suggested that the concomitant presence of acute coronary syndromes (ACS) and chronic obstructive pulmonary disease (COPD) is significantly associated with poor prognosis. It has been suggested that diagnosis of COPD is frequently missing. Thus, it is plausible that a significant percentage of patients with ACS may have unrecognized COPD. This missing diagnosis may contribute significantly to poor prognosis. The investigators suppose that the concomitant use of peak expiratory flow (PEF) measurement and of Respiratory Health Screening Questionnaire (RHSQ, adapted version) could be useful as screening test for COPD in patient smokers or former smokers admitted to hospital with a diagnosis of ACS. In all screened patients COPD diagnosis will be confirmed (or not) two months after hospital discharge with spirometry. In the same setting of patients, the investigators will characterize the underlying pathological mechanisms, evaluating several inflammation, platelet and endothelial markers.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY COPD Diagnosis |
39 | — |
| SECONDARY Cardiac Adverse Events |
8 | — |
| SECONDARY Undiagnosed COPD |
— | — |
Eligibility Criteria
Inclusion Criteria
- age >40 years
- typical chest pain during at least 20 minutes
- ST-segment changes on electrocardiography, indicating ischemia and/or positive test of a biomarker (troponin and/or CK-MB), indicating myocardial necrosis
- current or former history of smoking
Exclusion Criteria
- previous diagnosis of COPD and/or asthma
- known pulmonary disease
- ongoing pneumonia
- ongoing heart failure
- documented or suspicion of malignant disease
- life expectancy <1 year
- recent thoracic trauma
Data sourced from ClinicalTrials.gov (NCT02324660). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.