Phase 3
Completed N=40
Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus
Source: ClinicalTrials.gov NCT02329600 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Nov 2016
Primary outcomePrimary: Pain — 0; 4; 4.4 units on a scale
◆ Published Evidence
Highly cited
1,590citations · ~106 / year
Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications.
Summary
The study included forty individuals divided into 3 groups. 10 control subjects, 15 oral lichen planus (OLP) patients who were treated with topical corticosteroids and 15 oral lichen planus (OLP) patients who were treated with topical corticosteroids and green tea tablets.
Linked Publications (5)
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Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications.
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Direct scavenging of nitric oxide and superoxide by green tea.
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Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcinoma.
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Decreased antioxidant enzyme expression and increased oxidative damage in erosive lichen planus of the vulva.
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Green tea consumption: an alternative approach to managing oral lichen planus.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain |
0; 4; 4.4 | — |
| SECONDARY Salivary Total Oxidative Capacity |
6.37; 58.41; 23.27 | — |
Eligibility Criteria
Inclusion Criteria
- Patients presented with painful oral lichen planus lesions
- Free of any visible oral lesions other than oral lichen planus
- Free of any systemic diseases
Exclusion Criteria
- Topical treatment or systemic therapy of OLP for one month before starting the study
- Pregnant or breast feeding women
- Smokers
- Use of corticosteroids or other immunosuppressive drugs
Data sourced from ClinicalTrials.gov (NCT02329600) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.