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Oral Lichen Planus

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Oral Lichen Planus

8 trials tracked for Oral Lichen Planus: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 1590 citations.

8Trials tracked

3Phase 3 & 4

0Recruiting

1With published results

Phase distribution

Phase 4 1 Phase 3 2 Phase 2 3 Other / NA 2

Phase 3 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed · 1,590 cited
Phase 4 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed
Phase 3 Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Completed
Phase 2 Pimecrolimus Cream for Oral Lichen Planus Completed
Phase 2 Dexamethasone Solution and Dexamethasone in Mucolox™ Completed
Phase 2 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed

Show 2 more trials

N/A Salivary and Serum Leptin Levels in Oral Lichen Planus Patients: A Case-control Study. Completed
N/A Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Completed

Showing the 8 most-cited and recently-updated of 8 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Oral Lichen Planus: what the trials found

Lycopene treatment has been shown to significantly reduce the severity of lesions, specifically regarding reticular, erythematous, and ulceration components as measured by the Piboonniyom REU Severity Score (p=0.004) ¹. However, lycopene did not result in a statistically significant reduction in burning sensations or pain when measured by the Numerical Rating Scale (p=0.224) ¹.

Clinical trials have evaluated green tea tablets (Green tea extract 5:1) at a dosage of 200 mg for this condition ².

Recent results — preliminary, needs further review

Dexamethasone 0.5mg/5ml solution showed mean changes in oral pain scores and REU scores at 4 weeks, but these results are not yet corroborated ⁴.
Curcuminoids demonstrated a range of percent changes from baseline to two weeks in symptoms and signs of OLP ⁵.
Pimecrolimus 1% cream was evaluated in a Phase 2 trial ⁶.
Leptin was investigated in a study involving 78 participants ⁷.
Biopsy procedures demonstrated high sensitivity (100%) and specificity (90%) for identifying lesions stained positive ⁸.

For the clinician treating this condition

Lycopene is effective for reducing physical lesion severity (REU score) but does not significantly impact patient-reported pain or burning sensations ¹.
Green tea extract (5:1) at 200 mg is an established intervention in clinical trials ².

AI synthesis of 7 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.