N/A N=309 Randomized Prevention

A Comparison of Inhalation vs. Intravenous Induction

Hypothermia

Bottom Line

View on ClinicalTrials.gov: NCT02331108 ↗

Enrolled (actual)

309

Serious AEs

0.0%

Results posted

Apr 2017

Primary outcome: Primary: Measurement of Core Temperature — 36.42; 36.44; 35.96; 36.35 degree C

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Selection of anesthetic induction technique (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Albert Einstein Healthcare Network
Primary completion: Oct 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Measurement of Core Temperature	36.42; 36.44; 35.96; 36.35; 36.34; 36.41	—
PRIMARY Temperature Below 36.0 Degrees C	8; 8; 30; 8; 14; 14	—
SECONDARY Measurement of Blood Pressure	49; 29	—

Summary

To compart differences on the effect on core temperature between anesthetic induction with intravenous propofol versus inhalation induction with sevoflurane

Eligibility Criteria

Inclusion Criteria

Elective surgery Adult, age >= 18 years old Scheduled for general anesthesia Medically fit and able to safely go any of the four anesthetic inductions in the study

Exclusion Criteria

Emergency surgery, or any other aspiration risk Minor, age <18 Pregnant Febrile illness Contraindication to nasal instrumentation Allergy to propofol Malignant hyperthermia Requiring Total Invravenous Anesthesia (TIVA) Inability to oxygenate on less than 50% FiO2 Intra-cranial surgery Receiving vasoactive medications Significant valvular heart disease Unstable cardiac disease Surgery requiring prone or lateral positioning Contraindication to nitrous oxide Prisoners

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Data sourced from ClinicalTrials.gov (NCT02331108). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.