Phase 3 N=1,359 Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest
Out-of-hospital Cardiac Arrest
Primary: Number Alive at Hospital Discharge — 187; 183; 62; 76 participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=329 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial
Cardiac Arrest
Primary: Survival With Good Neurobehavioral Outcome — 48; 48; 85; 76 Participants — p=0.63
N/A N=168 Late Hypothermia for Hypoxic-Ischemic Encephalopathy
Infant, Newborn · Hypoxia, Brain · Hypoxia-Ischemia, Brain
Primary: Death or Moderate or Severe Disability — 19; 22 Participants
Phase 3 N=295 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial
Cardiac Arrest
Primary: Survival With Good Neurobehavioral Outcome — 27; 15; 111; 107 Participants — p=0.14
N/A N=389 Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients
Cardiac Arrest
Primary: Number of Participants With Death or Poor Neurologic Outcome at 6 Months — 89; 83 Participants
N/A N=141 Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Cardiac Arrest
Primary: Survival Rate - Number of Participants Alive — 55; 20; 32; 34 Participants — p=<0.001
N/A N=325 TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia
Asphyxia Neonatorum · Hypoxia · Encephalopathy
Primary: Combined Incidence of Mortality and Severe Neurodevelopmental Disability in Survivors — 74; 86 participants
N/A N=14 Heated Humidified Breathing Circuit Rewarming in Hypothermic Post Cardiopulmonary Bypass Patients.
Hypothermia · Rewarming
Primary: Time to Normothermia — 4.4 hours
N/A N=168 Preemie Hypothermia for Neonatal Encephalopathy
Infant, Newborn · Hypoxia, Brain · Hypoxia-Ischemia, Brain
Primary: Death or Moderate or Severe Disability — 29; 20 Participants
N/A N=101 California Transport Cooling Trial
Hypoxic Ischemic Encephalopathy
Primary: Percentage of Temperatures in Target Range During Transport — 0; 73 Percentage of temperatures — p=<0.001
Phase 2 N=30 Caffeinol Hypothermia Protocol
Acute Ischemic Stroke
Primary: Number of Participants With Symptomatic Intracerebral Hemorrhage — 0 participants
N/A N=5,056 Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
Perioperative Care · Surgery--Complications · Hypothermia; Anesthesia
Primary: Number of Participants With a Composite Outcome Consisted of Myocardial Injury After Non-cardiac Surgery (MINS), Non-fatal Cardiac Arrest, and All-cause Mortality — 239…
N/A N=10 Holding, Stress, and Bonding During Therapeutic Hypothermia
Hypoxic-Ischemic Encephalopathy
Primary: Frequency of Adverse Events (Safety) — 0 Participants
Phase 1 N=20 Reperfusion With Cooling in Cerebral Acute Ischemia
Stroke, Acute
Primary: Number of Participants With Reperfusion Injury Hemorrhagic Transformation — 3 participants
N/A N=375 Kangaroo Mother Care to Prevent Hypothermia in Term Infants
Hypothermia · Newborn
Primary: Number of Infants With Axillary Temperature <36.0 Degrees Celsius — 55; 56 Participants
N/A N=20 Cardiogenic Shock Intravascular Cooling Trial
Cardiogenic Shock
Primary: Number of Participants With Episodes of Arrhythmia — 0; 1 Participants — p=1
Phase 4 N=30 Body Temperature in Persons With Tetraplegia When Exposed to Cold
Tetraplegia · Hypothermia · Mild Cognitive Impairment
Primary: Visit 1: Percent Change in Core Body Temperature — -1.2; 0.05 Percent Change — p=<0.01
N/A N=42 Intraoperative Warming Comparison of Devices
Hypothermia
Primary: Percent of Patients With an Average Intraoperative Temperature Greater Than or Equal to 36 Celcius — 56; 90 percentage of participants — p=0.027
N/A N=22 Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
Cardiac Arrest
Primary: Microvascular Flow Index (MFI) — 1.7; 1.1 units on a scale
N/A N=738 Use of Hypothermia During Robotic Prostatectomy
Prostate Cancer
Primary: Feasibility and Safety Using an Improved, More Efficient and Less Labor Intensive Cooling Balloon in Patients Undergoing Hypothermic Nerve-sparing RLP in Participants…
N/A N=542 A Pilot Study of Intra-arrest Therapeutic Hypothermia in Patients Suffering Non-Traumatic Out of Hospital Cardiac Arrest
Out-of-Hospital Cardiac Arrest
Primary: Number of Participants Who Survived Up To Hospital Discharge — 24; 40 Participants
Phase 3 N=256 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy
Hypoxic-Ischemic Encephalopathy
Primary: Death — 27; 22 participants
N/A N=52 Neonatal Warming to Prevent Hypothermia
Hypothermia
Primary: Temperature at Arrival to Warmer — 36.9; 37.0 degrees Celsius
Phase 4 N=30 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia
Tetraplegia · Hypothermia · Mild Cognitive Impairment
Primary: Change in Core Body Temperature — -0.24; -0.97; NA; 0.79 °C — p=<0.001
N/A N=40 Pre-warming Prevents Hypothermia in Elective Cesarean Section
Hypothermia
Primary: Maternal Hypothermia — 36.6; 36.4; 36.5; 36.3 Centigrades — p=<0.05
N/A N=16 HypErthermia as an Additional Treatment for the Biology and Experience of Depression
Major Depressive Disorder
Primary: Average Number of Planned WBH Sessions Completed — 7.83; 3.20 Count of WBH Sessions
Phase 1 N=4 Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy
Hypoxic Ischemic Encephalopathy
Primary: Feasibility Trial- the Olympic Cool Cap Will be Applied, Can the Delivered Cap Temperature be Less Than 12 Degrees Without Changing Rectal Temperature. — 2 participants
N/A N=115 Telemedicine to Improve Use of Therapeutic Hypothermia in Rural Settings
Neonatal Encephalopathy
Primary: Time to Initiation of Therapeutic Hypothermia — 4.5 hours
Phase 4 N=20 Temperature Control in Central Fever in the Neuro-ICU
Fever · Brain Hemorrhage
Primary: Core Temperature as Measured With an Approved Device (Urinary Catheter) in Place for Usual Clinical Care — 100.8; 100.3; 99.9; 99.5 degrees F
N/A N=39 Warming Mattress Versus Polyethylene Wrapping to Prevent Hypothermia in Preterm Newborns.
Hypothermia
Primary: Neonatal Intensive Care Unit (NICU) Admission Temperature — 36.5; 36.1 Celsius degrees — p=0.445