Phase 4
Completed N=75
Anti-fatigue Effect of Korean Red Ginseng in Patients With Non-alcoholic Hepatitis
Source: ClinicalTrials.gov NCT02331589 ↗Enrolled (actual)
75
Serious AEs
—
Results posted
Feb 2015
Primary outcomePrimary: Liver Enzymes — 52.1; 59.1; 81.0; 81.6 U/L
Summary
Background: Korea red ginseng (KRG) has anti-carcinogenic activity, anti-oxidant activity, and cancer related anti-fatigue.
Methods: Seventy five patients with non-alcoholic hepatitis were prospectively randomized to receive 3 weeks of KRG or placebo. Liver function test, pro-inflammatory cytokines, adiponectin, fatigue severity scale, and antioxidant activity were check and compared.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Liver Enzymes |
52.1; 59.1; 81.0; 81.6; 106.9; 139.3 | — |
| SECONDARY Fatigue as Measured by KRUPP's Fatigue Severity Scale |
33.0; 29.8 | — |
| SECONDARY Pro-inflammatory Cytokine |
108.0; 123.1; 2.3; 1.5 | — |
| SECONDARY Adiponectin |
7751.2; 7711.6 | — |
Eligibility Criteria
Inclusion Criteria
- aspartate aminotransferase (AST) ≥ 50 U/L or alanine aminotransferase (ALT) ≥ 50 U/L, and Fatty liver or Hepatitis
Exclusion Criteria
- viral hepatitis, alcoholic hepatitis, autoimmune hepatitis, pancreatitis, hemochromatosis, Wilson's disease, drug induced liver injury, or cancer
Data sourced from ClinicalTrials.gov (NCT02331589). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.