Early Phase 1 N=32 Premature Fatigue in Veterans With Heart Failure: Neuronal Influences
Heart Failure
Primary: Maximal Voluntary Quadriceps Force [% Change From Baseline] — -30; -5 percentage change
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=20 Mechanisms to Reduce Mental and Physical Fatigue Following Exercise Training in Older Adults
Fatigue · Aging
Primary: Fatigue — -5.6; -4.1 change in fatigue severity score
N/A N=590 Fatigue Management Programs for People With MS
Multiple Sclerosis
Primary: Change From Baseline in Fatigue Levels — 50.98; 56.88; 57.87 score on a scale
Phase 4 N=60 The Effect of XueZhiKang on Fatigue：Comparing With Simvastatin
Dyslipidemias
Primary: Comparison Between XueZhiKang and Simvastatin on Fatigue Scores — 19.58; 21.58; 19.26; 19.33 units on a scale
Phase 3 N=8 ACTH for Fatigue in Multiple Sclerosis Patients
Multiple Sclerosis, Relapsing-Remitting
Primary: Fatigue at 28 Weeks — 56.50; 29.00; 55.00; 40.00 score on a scale
N/A N=25 Apollo Device for Fatigue in Systemic Sclerosis
Systemic Sclerosis · Fatigue · Raynaud Phenomenon
Primary: Change in PROMIS® Item Bank v1.0 - Fatigue - Short Form 13a (FACIT-Fatigue) at 4 Weeks (End-of-Study) Compared to Baseline — -7.0; 62.5 T-score — p=<0.001
Phase 2 N=45 MitoQ for Fatigue in Multiple Sclerosis (MS)
Multiple Sclerosis · Fatigue
Primary: Modified Fatigue Inventory Scale (MFIS) — 46.5; 55.2; 54.3; 45.1 units on a scale — p=0.9489
N/A N=50 SPARC Smartphone Application for the Management of Sarcoidosis-Associated Fatigue
Sarcoidosis · Fatigue
Primary: Proportion of Participants Recruited — 25; 25 Participants
Early Phase 1 N=64 Muscadine Grape Extract to Improve Fatigue
Fatigue
Primary: Patient Reported Outcomes Measurement System (PROMIS) Fatigue 7a Questionnaire — -6.6; -5.4 score on a scale
Phase 2 N=262 Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Adults With Fatigue Associated With Major Depressive Disorder
Major Depressive Disorder
Primary: Change in Clinical Global Impression of Severity (CGI-S) for Fatigue Score — -1.5; -1.8; -1.9 units on a scale
N/A N=181 Teleconference Fatigue Management for People With Multiple Sclerosis
Multiple Sclerosis
Primary: Change From Baseline in Subscale Scores of the Fatigue Impact Scale — -3.74; -1.22; -4.24; -1.11 units on a scale — p=<0.05
N/A N=12 Post-stroke Fatigue, Inflammation, tDCS
Stroke · Fatigue · Chronic Stroke
Primary: Change in Fatigue Severity Scale (FSS) Score — -0.4; 0.2 units on a scale
N/A N=15 Self-Management of Cancer-Related Fatigue by Adolescents
Neoplasms · Fatigue
Primary: Change From Baseline in Fatigue Scale-Adolescent (FS-A) Score Categorized According to 1-5 Rating Scale of Resource Use and Resource Helpfulness. — -3; -3; -4; -4 units…
N/A N=12 Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability
Fatigue · Aging
Primary: Change in Muscle Fatigue After 1 Week of Placebo or Sildenafil — 107; 115; 54; 158 percent change of successful repetitions — p=0.02
Phase 3 N=190 Methylphenidate and a Nursing Telephone Intervention for Fatigue
Advanced Cancer · Fatigue
Primary: Change in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Fatigue Subscale Score — 4.00; 7.00; 8.50; 5.00 score on a scale — p=0.16
Phase 4 N=26 Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome
Chronic Fatigue Syndrome · Cognitive Impairments
Primary: Change in BRIEF-A — 21.38; 3.36 Scores on a scale — p=.005
N/A N=18 The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue
Fatigue
Primary: Skeletal Muscle Fatigue as Measured by Biodex 4 Pro After 4 Weeks of Placebo — 59.69; 42.07; 67.17; 63.24 Newton-Meters
Phase 2 N=19 Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis
Multiple Sclerosis · Internuclear Ophthalmoplegia · Fatigue
Primary: Pulse Size Ratio (PSR): Abducting/Adducting Eye Ratio for Saccadic Peak Velocity. — 1.914; 1.937; 1.805; 1.898 ratio — p=0.842672
Phase 2 N=12 A Rehabilitation Therapy for Post-stroke Fatigue
Stroke
Primary: Feasibility of Recruitment Process — 120; 49; 20; 12 participants
N/A N=47 Step-Up Intervention for Self-Management of Fatigue in Young Adults Receiving Chemotherapy
Young Adult, Cancer, Physical Activity
Primary: Self-efficacy for Physical Activity — 62.6; 56.2 score on a scale — p=0.22
N/A N=693 An Observational Study of the Impact of RoActemra/Actemra on Fatigue in Patients With Rheumatoid Arthritis (PEPS)
Rheumatoid Arthritis
Primary: Percentage of Participants With a Clinically Significant Improvement in Fatigue After 4 Months of Tocilizumab Treatment — 63.3 Percentage of participants
N/A N=34 Blood Lactate Concentrations With and Without Exercise in Parkinson's Disease and Multiple Sclerosis Patients
Parkinson's Disease · Multiple Sclerosis
Primary: Blood Lactate Response — 1.7; 1.6; 1.2; 2.3 mmol/L
N/A N=171 Acupressure for Fatigue in Ovarian Cancer Survivors
Fatigue · Ovarian Cancer
Primary: Change in Level of Fatigue at Week 6 — 5.57; 5.30; 5.38; 3.52 mean score
N/A N=30 Muscle Fatigue and Scapular Sensorimotor System
Muscle; Fatigue
Primary: Change From Baseline in Scapular Proprioception — -0.48; -0.19; -0.37; -0.32 centimeters — p=0.227
N/A N=30 Impact of Nutritional Supplementation on Aerobic Performance and Fatigue
Performance · Fatigue
Primary: Perceived Exertion — 6.7; 7.4 units on a scale
N/A N=64 Telehealth-Based Exercise Program to Treat Fatigue in MS
Multiple Sclerosis
Primary: Fatigue — 53.78; 49.65; 45.76; 50.53 units on a scale — p=.013
N/A N=108 Omega-3 Fatty Acid in Reducing Cancer-Related Fatigue in Breast Cancer Survivors
Breast Carcinoma · Cancer · Fatigue
Primary: Mean Change (6 Weeks - Baseline) and Standard Deviation in Cancer-related Fatigue, Using the Brief Fatigue Inventory-Short Form (BFI-SF) and Multidimensional Fatigue…
N/A N=60 Feasibility of Light Therapy for Fatigue N-of-1 Trials
Fatigue
Primary: Mean System Usability Score (SUS). — 78.89 score on a scale
Phase 4 N=30 Rasagiline for the Symptomatic Treatment of Fatigue in Parkinson's Disease
Parkinson's Disease
Primary: Modified Fatigue Impact Scale (MFIS) — 12.92; 12.69 units on a scale — p=0.81
N/A N=47 Integrative Medicine Consultation for Patients With Pain or Fatigue
Pain · Fatigue
Primary: Short Form 36 (SF-36) Physical Component Summary (PCS) — 36.2; 39.0 Scores on a scale — p=0.487