Positron Emission Tomography (PET) Study Investigating Dopamine and Serotonin Receptor Occupancy After Multiple Oral Dosing of Lu AF35700

Inclusion Criteria

• The patient is a man aged between ≤18 and ≥60 years
• BMI of ≥19 kg/m2 to ≤ 37 kg/m2
• The patient has a primary diagnosis of schizophrenia according to DSM-5™ (code 295.90)
• The patient has a Clinical Global Impression - Severity of Illness (CGI-S) score ≤ 4 (moderately ill) at screening and safety baseline
• The patient is currently under oral therapy with one or more of the antipsychotic medications listed in Appendix II.
• The patient has a Positive and Negative Syndrome Scale (PANSS) total score ≤ 80
• The patient has a score of ≤ 4 (moderate) on the following PANSS items at screening and at safety baseline: P7 (hostility), G8 (uncooperativeness)

Exclusion Criteria

• The patient experienced an acute exacerbation requiring hospitalization within the last 3 months.
• The patient experienced an acute exacerbation requiring change in antipsychotic medication (with reference to drug or dose) within the last 4 weeks.
• The patient has a diagnosis or history of substance use disorder (except nicotine) according to DSM-5-TR® criteria ≤3 months prior to screening
• The patient is at significant risk of harming himself or others according to the investigator's judgment or as indicated by an answer of "yes" to the question 4 or 5 on the Columbia-Suicide Severity Rating Scale (C-SSRS) at the Screening Visit within the last six months on the lifetime version of C-SSRS.
• Based on investigators judgment the patient has a medical or neurological disorder or treatment for such disorder that could interfere with the study treatment or impair treatment compliance.
• The patient has had past episodes of extrapyramidal symptoms (EPS) under current medication within the last 3 month
• The patient takes other medication than those listed as allowed concomitant medication in Appendix III
• The patient is occupationally exposed to significant levels of ionizing radiation.

Other protocol-defined inclusion and exclusion criteria may apply