N/A
Completed N=49
Cognitive Dysfunction in Parkinson's Disease
Source: ClinicalTrials.gov NCT02346708 ↗Enrolled (actual)
49
Serious AEs
2.2%
Results posted
Dec 2020
Primary outcomePrimary: Change in Magnetoencephalography (MEG) Connectivity Measures
Summary
This study plans to learn more about the brain function related to thinking problems in individuals with Parkinson's disease.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Magnetoencephalography (MEG) Connectivity Measures |
— | — |
| SECONDARY Post-TMS Change From Baseline in Cognitive Scores |
-1.4; 0; 0.3; 1; -9.1; -2.9 | 0.1 |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of probable PD (using United Kingdom Brain Bank criteria)
- Diagnosis of mild cognitive impairment
- No unstable medical condition
Exclusion Criteria
- Features suggestive of other causes of Parkinsonism or other neurological disorders
- Prior deep brain stimulation (DBS) or ablation surgery
- Evidence for active depression or Hospital Anxiety and Depression Scale (HADS) score greater than or equal to 11
- Motor symptoms expected to interfere with scanning (e.g. sever tremor)
- Contraindications to TMS, MEG, or MRI such as pregnancy, pacemaker, unstable cardiac disease, skull lesion, claustrophobia, history of epilepsy, or on medications known to lower seizure threshold
- Implanted electronic devices or metal
Data sourced from ClinicalTrials.gov (NCT02346708). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.