N/A
Completed N=602
Early Risk Stratification in ED Chest Pain Patients
Source: ClinicalTrials.gov NCT02364271 ↗Enrolled (actual)
602
Serious AEs
4.3%
Results posted
Apr 2021
Primary outcomePrimary: Number of Patients With Major Adverse Cardiac Event — 42; 0; 437; 123 Participants
Summary
In the management of adult chest pain patients presenting to an Emergency Department (ED) with suspected acute coronary syndrome (ACS), we aimed to evaluate the diagnostic accuracy of the combined use of a modified Thrombolysis in Myocardial Infarction (TIMI) score and a modified HEART score with high-sensitive cardiac troponin T (hs-cTnT) to rule out major adverse cardiac events (MACE) in 30-days.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Patients With Major Adverse Cardiac Event |
42; 0; 437; 123 | — |
| SECONDARY Number of Safety Major Adverse Cardiac Event |
31; 0 | — |
| SECONDARY Number of Effecacy MACE |
26; 0 | — |
Eligibility Criteria
Inclusion Criteria
- Aged 18 years or over
- Chest pain within 24 hours of ED presentation
- Suspected with ACS
Exclusion Criteria
- No cardiac chest pain based on clinical assessment
- Hemodynamic or clinical instability (SBP<90 mmHg, clinically significant atrial/ventricular arrhythmias)
- Initial ECG suggestive of ACS, Acute Myocardial Infarction or other abnormality requiring admission to hospital
- Previous coronary artery bypass grafting or coronary stent implantation
- Women with known or suspected pregnancy
- Unable or unwilling to provide informed consent
- Unable to be contacted after discharge
- Contraindication to β-blockade if prescription of β-blockade is required due to a resting heart rate over 80 beats per minute
Data sourced from ClinicalTrials.gov (NCT02364271). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.