N/A
Completed N=8
Effectiveness of Prazosin in Bulimic Patients Experiencing Nightmares Due to PTSD
Stress Disorders, Post-Traumatic · Bulimia Nervosa
Source: ClinicalTrials.gov NCT02382848 ↗
Enrolled (actual)
8
Serious AEs
0.0%
Results posted
Jul 2019
Primary outcomePrimary: Decrease in Frequency of Nightmares Using the Sleep-50 Questionnaire — 2.25; 2.75 score on a scale
Summary
This research is being done to find out how effective Prazosin is in the treatment of bulimic patients experiencing distressing nightmares using subjective and objective measures.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Decrease in Frequency of Nightmares Using the Sleep-50 Questionnaire |
2.25; 2.75 | — |
| PRIMARY Decrease in Rapid Eye Movement (REM) Density & Normalization of REM Disruptions |
— | — |
| SECONDARY Decrease in Bulimia Symptoms |
43.1; 38.6 | — |
| SECONDARY Decrease in Total CAPS Score (PTSD) |
65.5; 79.8 | — |
| SECONDARY Decrease in Depressed Mood as Measured by the HDRS (Hamilton Depression Rating Scale) and Subject Interview |
1.4; 1.3 | — |
| SECONDARY Decrease in Self Harm Thoughts as Measured by the HDRS and Subject Interview |
0.5; .1 | — |
Eligibility Criteria
Inclusion Criteria
- Age 18-45
- Clinical diagnosis of Bulimia Nervosa with complaint of nightmares secondary to PTSD
Exclusion Criteria
- Restless leg syndrome
- Narcolepsy
- Sleep Apnea
- Neurological disorders
- Pregnancy
- cardiac abnormalities
- significant electrolyte abnormalities
- Use of steroids, beta blockers, prazosin
- Alcohol/substance abuse
Data sourced from ClinicalTrials.gov (NCT02382848). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.