Phase 4
Completed N=183
IV Acetaminophen for Postoperative Pain Analgesia After Laparoscopic Hysterectomy
Source: ClinicalTrials.gov NCT02400580 ↗Enrolled (actual)
183
Serious AEs
0.5%
Results posted
Dec 2017
Primary outcomePrimary: Postoperative Pain — 3.55; 3.11 units on a visual analog scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The objective of this study is to quantify the change in post-operative pain scores and narcotic requirements in women receiving pre and post-operative IV acetaminophen compared to placebo in women undergoing laparoscopic hysterectomy.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postoperative Pain |
3.55; 3.11 | — |
| SECONDARY Narcotic Medication Use |
16.4; 18.4 | — |
Eligibility Criteria
Inclusion Criteria
- Women aged 18-75
- Ability to read and write in English (our post-operative pain log is only available in English)
- Planning a laparoscopic hysterectomy (includes total laparoscopic hysterectomy, laparoscopic supracervical hysterectomy, laparoscopically assisted vaginal hysterectomy, with or without salpingooophorectomy)
Exclusion Criteria
- Answering yes to any of the following questions: "Do you have a history of liver disease, kidney disease, hepatitis C, history of liver failure, greater than 3 drinks per day or being have you ever been told by your doctor that they should not take acetaminophen"
- History of cardiac arrhythmia
- History of jaundice
- Acute abdominal inflammatory or infectious process at time of surgery
- Known malignancy at time of surgery
- Known pregnancy at time of surgery
- Plan to perform additional significant surgical procedure at the time of hysterectomy such as extensive excision of endometriosis on bowel or bladder or pelvic reconstructive procedure
- >6cm abdominal incision in order to remove the uterus at time of study-related hysterectomy
- Regular use of narcotic pain medication (defined as use on most days of the week at any point in the past 3 months)
- Allergy to acetaminophen
- Women who weigh less than 50 kilograms on the day of surgery.
Data sourced from ClinicalTrials.gov (NCT02400580). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.