N/A
N=7
Brain Metabolism in Polycystic Ovary Syndrome
Insulin Resistance
Bottom Line
View on ClinicalTrials.gov: NCT02409914 ↗Enrolled (actual)
7
Serious AEs
—
Results posted
May 2019
Primary outcome: Primary: Global Brain Glucose PET Uptake — 34.9 umol/100 g/min
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Université de Sherbrooke
- Primary completion
- Sep 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Global Brain Glucose PET Uptake |
34.9 | — |
| PRIMARY Brain MR Volumes |
22.6; 10.3 | — |
| PRIMARY Insulin Resistance (HOMA2-IR) |
0.7 | — |
Summary
The purpose of this study is to investigate whether higher insulin resistance in young women with Polycystic ovary syndrome (PCOS) is associated with reduced cerebral metabolic rate of glucose (CMRglu). Brain volumes using magnetic resonance imaging (MRI) and quantitative cerebral glucose uptake using dynamic positron emission tomography (PET) were obtained.
Eligibility Criteria
Inclusion Criteria
- Diagnosis of PCOS
- Age ≤ 35 y
- BMI ≤ 35
Exclusion Criteria
- Taking medications for diabetes or insulin-sensitizing drugs
- Drug addictions
- Psychiatric illness
- Smoking
- Overt evidence of heart, liver or renal disease
Data sourced from ClinicalTrials.gov (NCT02409914). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.