Narrative review links microgravity exposure to altered fat distribution and inflammation in metabolic disease models.
How Space Travel Is Unlocking New Ways to Fight Obesity and Diabetes
This narrative review synthesizes evidence from human studies, animal models, and in vitro experiments regarding microgravity and metabolic …
This research shows that the same health problems astronauts face in space are happening to people on Earth who sit too much, and it may lea…
IGFBP2 as a context-dependent regulator of metabolic dysregulation in obesity and type 2 diabetes
IGFBP2 may signal metabolic changes in obesity and diabetes, but human proof is still missing.
This review examines IGFBP2 as a potential translational indicator of metabolic dysregulation in conditions including obesity, insulin resis…
A protein called IGFBP2 might signal metabolic changes in obesity and diabetes, but human proof is still missing.
Narrative review explores adipose tissue macrophage regulation for obesity and metabolic disorders
The Immune Cells Inside Fat Tissue That Drive Obesity's Hidden Damage
This narrative review examines targeted regulation of adipose tissue macrophages (ATMs) via mitochondrial, extracellular vesicle, probiotic,…
Specialized immune cells hiding inside your fat tissue are quietly driving the chronic inflammation that damages your heart, liver, and panc…
Phase II RCT: Amiloride reduces arterial stiffness and blood pressure in adults with obesity and metabolic syndrome
Low-dose amiloride reduced arterial stiffness and blood pressure in adults with obesity
A phase II, single-center RCT of 137 adults with overweight/obesity and metabolic syndrome features found 24 weeks of low-dose amiloride (5 …
Low-dose amiloride reduced arterial stiffness and blood pressure in adults with obesity, offering a potential new tool to improve heart heal…
Insulin resistance indicators TyG-BMI and METS-IR associated with pregnancy loss in recurrent pregnancy loss cohort
Insulin resistance markers linked to pregnancy loss risk in women with prior losses
A cohort study of 897 women with recurrent pregnancy loss found that the highest tertiles of TyG-BMI and METS-IR were associated with increa…
High insulin resistance markers found in women with prior miscarriages significantly increase the risk of another pregnancy loss.
GWAS identifies 282 insulin resistance loci, links to fat distribution and candidate mediators
Large genetic study identifies hundreds of DNA regions linked to insulin resistance
A multi-trait GWAS and Mendelian Randomization study in up to 1.25 million individuals identified 282 insulin resistance-associated loci, in…
A massive genetic study found 282 DNA regions linked to insulin resistance, revealing how fat storage patterns and specific proteins drive m…
Network meta-analysis compares exercise types for insulin resistance in youth with overweight or obesity
Which exercise works best for insulin resistance in kids with extra weight?
A network meta-analysis of 63 RCTs involving 3,286 children and adolescents with overweight or obesity compared exercise modalities. HIIT wa…
For kids with extra weight, short bursts of intense exercise best lower insulin levels, while mixing cardio and weights works best for dropp…
Psychotropic medications frequently cause metabolic adverse effects via gut-brain axis
Why do psychiatric medications often cause weight gain and diabetes?
A narrative review synthesizes emerging evidence on psychotropic-induced metabolic disturbances. Psychotropic medications frequently cause w…
Psychiatric drugs often cause weight gain and diabetes by disrupting the gut-brain-metabolic axis, a link new science is starting to map.
METS-IR shows U-shaped link to gallstone disease risk, with inflection at 29.83
Could your body's insulin resistance score reveal your risk for gallstones? A new study finds a surprising U-shaped link.
A cohort study of 52,723 participants found a nonlinear U-shaped association between the Metabolic Score for Insulin Resistance (METS-IR) an…
A new study of over 52,000 people found that your metabolic score for insulin resistance (METS-IR) has a surprising link to gallstone risk. …