N/A N=75 Randomized Quadruple-blind Treatment

Intravenous Dexamethasone to Increase the Analgesic Duration of Interscalene Block

Pain

Bottom Line

View on ClinicalTrials.gov: NCT02412657 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Apr 2016

Primary outcome: Primary: Duration of Analgesia — 19.1; 19.6; 11.8 hours

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Dexamethasone (Drug); Normal Saline (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Maisonneuve-Rosemont Hospital
Primary completion: Oct 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Duration of Analgesia	19.1; 19.6; 11.8	—
SECONDARY Pain Scores	—	—
SECONDARY Residual Motor Block	—	—
SECONDARY Sleep Disturbance	—	—
SECONDARY Patients Overall Satisfaction	—	—

Summary

Interscalene brachial plexus block provides excellent but time limited analgesia. Intravenous dexamethasone increases the analgesic duration of a single-shot interscalene block with ropivacaine for shoulder arthroscopic surgery. We want to evaluate the effect of two different doses (dexamethasone 10 mg i.v. vs 4 mg i.v. vs placebo) on the analgesic duration of a single-shot inter scalene block. Our study hypothesis is that dexamethasone 4 mg i.v. is equivalent to dexamethasone10 mg i.v. in prolonging the analgesic duration of a single-shot interscalene block with ropivacaine.

Eligibility Criteria

Inclusion Criteria

Elective shoulder arthroscopy under ropivacaine single-shot interscalene brachial plexus block anesthesia (rotator cuff repair and shoulder decompression)
ASA I-III
Age 18-80 years old

Exclusion Criteria

Any contraindication to interscalene brachial plexus block anesthesia
Interscalene brachial plexus block failure
Known local anesthetics allergy
Dexamethasone allergy or intolerance
Any contraindication to acetaminophen
Any contraindication to morphine or hydromorphone
Brachial plexus neuropathies
Chronic pain syndrome other than shoulder pain
Routine use of opioid medication
Routine use of systemic corticosteroid
Pregnancy
Weight below 50 kilograms
Incapability to understand a numeric verbal pain scale
Incapability to consent
Patient refusal

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Data sourced from ClinicalTrials.gov (NCT02412657). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.