N/A
Completed N=68
Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses
Source: ClinicalTrials.gov NCT02440204 ↗Enrolled (actual)
68
Serious AEs
0.0%
Results posted
Jan 2019
Primary outcomePrimary: EC50 for Successful Intubation in Each Groups — 3.00; 2.00; 1.29 vol%
Summary
Intubation is a procedure that requires well relaxed muscles while general anesthesia is performed. In order to get adequate muscle relaxation, remifentanil, sevoflurane or both agents in combination have been reported as they can provide adequate conditions for laryngoscopy and tracheal intubation without using muscle relaxants.
However, there were no previous studies to find the effective dose of sevoflurane in combination with different bolus doses of remifentanil to obtain adequate endotracheal intubation conditions without using muscle relaxants. The aim of this study is to investigate the change in the minimum sevoflurane alveolar concentration which produces an adequate endotracheal intubation condition when sevoflurane is combined with different bolus doses of remifentanil used in clinical practice.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY EC50 for Successful Intubation in Each Groups |
3.00; 2.00; 1.29 | — |
| SECONDARY EC95 for Successful Intubation |
3.45; 2.91; 1.89 | — |
Eligibility Criteria
Inclusion Criteria
- American Society of Anesthesiologists physical status I or II who were scheduled to undergo elective otolaryngological surgery
Exclusion Criteria
- history of reactive airway disease
- smoking hx.
- a predictive signs of difficult intubation
- body mass index ≥ 30 kg•m-2 or ≤ 15 kg•m-2
Data sourced from ClinicalTrials.gov (NCT02440204). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.