N/A
N=68
Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses
Postoperative Pain
Bottom Line
View on ClinicalTrials.gov: NCT02440204 ↗Enrolled (actual)
68
Serious AEs
0.0%
Results posted
Jan 2019
Primary outcome: Primary: EC50 for Successful Intubation in Each Groups — 3.00; 2.00; 1.29 vol%
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Intubation (Procedure); Remifentanil (Drug); Sevoflurane (Drug)
- Age
- Adult · 19+ yrs
- Sex
- Male
- Sponsor
- Severance Hospital
- Primary completion
- Apr 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY EC50 for Successful Intubation in Each Groups |
3.00; 2.00; 1.29 | — |
| SECONDARY EC95 for Successful Intubation |
3.45; 2.91; 1.89 | — |
Summary
Intubation is a procedure that requires well relaxed muscles while general anesthesia is performed. In order to get adequate muscle relaxation, remifentanil, sevoflurane or both agents in combination have been reported as they can provide adequate conditions for laryngoscopy and tracheal intubation without using muscle relaxants.
However, there were no previous studies to find the effective dose of sevoflurane in combination with different bolus doses of remifentanil to obtain adequate endotracheal intubation conditions without using muscle relaxants. The aim of this study is to investigate the change in the minimum sevoflurane alveolar concentration which produces an adequate endotracheal intubation condition when sevoflurane is combined with different bolus doses of remifentanil used in clinical practice.
Eligibility Criteria
Inclusion Criteria
- American Society of Anesthesiologists physical status I or II who were scheduled to undergo elective otolaryngological surgery
Exclusion Criteria
- history of reactive airway disease
- smoking hx.
- a predictive signs of difficult intubation
- body mass index ≥ 30 kg•m-2 or ≤ 15 kg•m-2
Data sourced from ClinicalTrials.gov (NCT02440204). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.