N/A Completed N=178 Randomized Double-blind Supportive Care

Brain Connectivity and Response to Tai Chi in Geriatric Depression

Major Depressive Disorder

Source: ClinicalTrials.gov NCT02460666 ↗

Enrolled (actual)

178

Serious AEs

0.0%

Results posted

Jul 2021

Primary outcomePrimary: Change in Hamilton Depression Rating Scale (HDRS) Scores — -9.27; -9.40 units on a scale — p=0.3

Summary

The purpose of this study is to evaluate the effects after up to 1 year of supervised weekly Tai-Chi-Chi versus Health Education and Wellness classes on reduction of depressive symptoms and improvement in resilience, health functioning, quality of life, cognition, sleep, fMRI neural correlates of working memory, and brain structure.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Hamilton Depression Rating Scale (HDRS) Scores	-9.27; -9.40	0.3
SECONDARY Change in Delayed Recall Cognitive Domain Scores	-0.15; -0.002	0.2
SECONDARY Change in Attention/Executive Function Cognitive Domain Scores	-0.04; 0.03	0.5
SECONDARY Change in Language Cognitive Domain Scores	0.03; -0.12	0.09

Eligibility Criteria

Inclusion Criteria

A 24-item Hamilton Rating Scale for Depression (HAMD) score greater than 14 consistent with moderate-severe depression.
Mini-Mental State Exam (MMSE) score greater than 24.
Sufficient English proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV.
Capacity to provide informed consent.
A stable form of treatment for at least 4 months.

Exclusion Criteria

Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
Any disabilities preventing their participation in Tai-Chi Chih exercise (e.g. severe visual or hearing impairment)
Insufficient English proficiency
Diagnosis of dementia
Mini Mental Health Examination score of 24 and below
Effective antidepressant, psychotropic medications, or effective therapy
Participation in a psychotherapy that involves cognitive training
Do not meet criteria for moderate-severe depression with a 24-item Hamilton Rating Scale for Depression (HAMD) score less than 14

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02460666). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.