Phase 2
Completed N=46
Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis
Source: ClinicalTrials.gov NCT02469597 ↗Enrolled (actual)
46
Serious AEs
0.0%
Results posted
Aug 2016
Primary outcomePrimary: Respiratory Rate — -3.7; -1.7 Percentage change in respiratory rate
Summary
The purpose of this study is to assess if administration of an early single dose of a diuretic (furosemide) to children with moderate to severe bronchiolitis can reduce extravascular lung water in an effort to reduce respiratory rate, retractions, intubations, and length of stay.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Respiratory Rate |
-2.8; -5.4 | — |
| PRIMARY Oxygen Saturation |
-0.19; 0.29 | — |
| SECONDARY Patient Needing Endotracheal Intubation |
0; 0 | — |
| SECONDARY Length of Hospital Stay |
3.1; 3.0 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of Acute Bronchiolitis
- Admission required per Emergency Department Physician
Exclusion Criteria
- No legal guardian present
- Sulfa allergy
- Patient currently on existing diuretic therapy
- Tracheostomy
- Mild respiratory distress (not requiring admission)
- Hypotension / Hemodynamic Instability (defined by age specific criteria at time of intervention)
- Supplemental Oxygen at home
- History of Dialysis / Renal Disease
- Those enrolled in another drug interventional study
Data sourced from ClinicalTrials.gov (NCT02469597). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.