N/A
N=41
Effect of Heat Exposure on Cognition in Persons With Tetraplegia
Tetraplegia · Hypothermia · Mild Cognitive Impairment
Bottom Line
View on ClinicalTrials.gov: NCT02488824 ↗Enrolled (actual)
41
Serious AEs
0.0%
Results posted
Nov 2019
Primary outcome: Primary: Change in Core Body Temperature From Baseline to 120 Minutes Post Warm Challenge — 0.59; -0.05 degrees Centigrade
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Warm Temperature (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Sep 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Core Body Temperature From Baseline to 120 Minutes Post Warm Challenge |
0.59; -0.05 | — |
| PRIMARY Change in Cognitive Performance From Baseline to 120 Minutes Post Warm Challenge |
6.2; 2.1; 1.6; 0.3 | — |
| SECONDARY Change in Distal Skin Temperatures From Baseline to 120 Minutes Post Warm Challenge |
3.9; 3.9 | — |
| SECONDARY Change in Sweat Rate From Baseline to 120 Minutes Post Warm Challenge |
24.9; 77.0 | — |
| SECONDARY Change in Thermal Sensitivity From Baseline to 120 Minutes Post Warm Challenge |
3.3; 2.6 | — |
Summary
The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (<95 F) have been documented in this population after exposure to even mild environmental temperatures. However, no work to date has addressed the effect of subnormal Tcore on cognitive performance in persons with tetraplegia despite studies with able-bodied (AB) individuals that have documented progressive decline in various aspects of cognitive performance associated with the magnitude of the depression in Tcore. The investigators' study will confirm and extend their initial observations in persons with higher cord lesions who have subnormal Tcore to show that cognitive performance will be improved by raising Tcore to euthermic levels. This improvement should be associated with greater function and independence, reintegration into society, and an improved quality of life.
Specific Aims: During exposure to 95 F for up to 120 minutes in the seated position, the investigators' aims are:
Primary Specific Aim: To determine if a modest rise in Tcore to euthermic levels has a positive effect on cognitive performance (attention, working memory, processing speed, and executive function) in persons with higher-level spinal cord injury (SCI).
Primary Hypothesis: Based on the investigators' pilot data: (1) 80% of persons with SCI will demonstrate an increase of 1 F in Tcore, while none of the AB controls will demonstrate such an increase; (2) 80% of persons with SCI will have an improvement of at least one T-score in Stroop Interference scores (a validated measure of executive function), while none of the AB controls will demonstrate a change in cognitive performance.
Secondary Specific Aim: To determine changes in: (1) The average of distal skin temperatures; (2) Sweat rate; and (3) Subjective rating of thermal sensitivity.
Secondary Hypothesis: Persons with SCI will have less of a percent change in average distal skin temperatures and sweat rate, and will report blunted ratings of thermal sensitivity compared to that of AB controls.
Eligibility Criteria
Inclusion Criteria
- Duration of injury 1 year
- Level of SCI C3-T4, AIS A & B
- Tcore at BL <98.6 F (subnormal core body temperature)
- Euhydration
- Gender and age-matched ( 5 years) AB controls (between 18-68 years of age)
Exclusion Criteria
- Known heart, kidney, peripheral vascular, or cerebral vascular disease
- High blood pressure
- History of traumatic brain injury or diagnosed cognitive impairment
- Untreated thyroid disease
- Diabetes mellitus
- Acute illness or infection
- Dehydration
- Smoking
- Pregnancy
- Broken, inflamed, or otherwise fragile skin
Data sourced from ClinicalTrials.gov (NCT02488824). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.