Framingham cohort links longitudinal brain atrophy patterns to cognitive decline and AD biomarkers in community-based participants
Brain shrinkage patterns predict Alzheimer's risk in older adults
This community-based cohort study of 300 participants from the Framingham Heart Study analyzed longitudinal brain atrophy patterns using MRI…
A study of 300 older adults found specific brain shrinkage patterns that strongly predict Alzheimer's disease and worse thinking skills.
Pilot study assesses safety and feasibility of young donor plasma replacement in mild cognitive impairment
Twelve patients with early memory loss received young donor blood plasma safely.
This pilot study examined the safety and feasibility of replacing patient plasma with that from young donors in twelve individuals with mild…
Twelve patients with early memory loss received young donor blood plasma safely. The procedure was feasible and well tolerated.
Network meta-analysis finds PUFA supplements may benefit cognition in mild cognitive impairment
Fatty acids could improve thinking in mild memory loss
This systematic review and network meta-analysis of 2,451 elderly participants with mild cognitive impairment found that PUFA supplements sh…
New analysis suggests certain fatty acids may help older people with mild memory loss think better and function well.
Review of cross-sectional EEG study on 32-Hz stimulation in Alzheimer's disease and mild cognitive impairment
Why Some Brains Respond Better to Gamma Stimulation in Alzheimer's
This review summarizes a cross-sectional EEG study evaluating 32-Hz visual stimulation in adults aged 55 years or older with Alzheimer's dis…
People with lower cognitive reserve showed bigger brain network changes during gamma stimulation, suggesting who might benefit most.
AI-driven home cognitive program improves global cognition in older adults with MCI
AI Home Program Boosts Memory Scores In Older Adults With Mild Memory Loss
This randomized controlled trial in 62 older adults with mild cognitive impairment found that a 5-week AI-driven home cognitive rehabilitati…
A new AI home program significantly improved memory scores in older adults, offering a hopeful new path for brain health without leaving hom…
Olfactory decline associated with conversion to mild cognitive impairment and dementia in unimpaired adults.
Losing your sense of smell might warn of memory loss
This retrospective longitudinal analysis of 922 cognitively unimpaired individuals found olfactory decline associated with conversion to mil…
Losing your sense of smell could warn of memory loss years before symptoms appear in older adults seeking help.
Cross-sectional study observes differences in cardiovascular regulatory responses in mild cognitive impairment
Researchers find heart rhythm changes linked to mild cognitive impairment
This cross-sectional observational study investigated cardiovascular regulatory responses to acute cognitive stress in community-dwelling ol…
New observations suggest that how the heart responds to mental stress may differ in people with early signs of memory loss.
Review of MRI radiomic features aids Alzheimer's disease classification and progression modeling in 382 participants.
MRI Scan Finds Alzheimer's Signs Before Memory Loss Starts
This observational review synthesizes findings from 382 participants across three cognitive stages regarding MRI-derived radiomic features. …
New imaging tools might catch Alzheimer's changes years before memory fades.
Meta-analysis finds trivial cognitive effects of amyloid antibodies in mild Alzheimer's disease
Alzheimer’s Drugs Clear Plaques But Don’t Help Memory
This meta-analysis of 17 randomized trials found amyloid-beta-targeting monoclonal antibodies probably have little to no effect on cognitive…
This review shows that even when Alzheimer’s drugs clear amyloid from the brain, patients don’t see meaningful improvements in memory or dai…
Virtual reality cognitive training shows benefit on cognition in older adults with mild cognitive impairment
Virtual Reality Training Helps Older Adults Keep Their Minds Sharp
This PRISMA-guided systematic review and meta-analysis of randomized controlled trials pooled 19 studies identified from 2,433 screened reco…
Virtual reality training helps older adults with mild cognitive impairment improve memory and daily living skills without boring homework.
Review of bilingualism effects on naming performance in Catalan-Spanish speakers with cognitive impairment
Why Knowing Two Languages Changes the Story
This narrative review synthesizes observational evidence on bilingualism and naming performance in Catalan-Spanish bilinguals with Alzheimer…
Active bilinguals with early memory loss made more naming errors than those who only knew one language well, showing that fluency matters fo…
REDDI pipeline improves balanced accuracy for classifying MCI, MS, Parkinson's, and ALS using MEG data.
Can a new computer tool help doctors spot brain diseases faster and more accurately?
This study developed a machine learning framework called REDDI that utilizes MEG resting-state data and Riemannian geometry for classifying …
A new computer tool helps doctors distinguish between hard-to-tell-apart brain diseases like Parkinson's and ALS with 13% better accuracy.