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Home › Conditions › Mild Cognitive Impairment

Mild Cognitive Impairment

Part of Cognitive Dysfunction

82 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Mild Cognitive Impairment

230 trials tracked for Mild Cognitive Impairment: 26 in phase 3 or 4 and 9 with published results. The most-cited published study has 851 citations.

230Trials tracked
26Phase 3 & 4
0Recruiting
9With published results
Phase distribution
Phase 4 13 Phase 3 13 Phase 2 47 Phase 1 6 Other / NA 151
  1. Phase 3 Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases Completed · 851 cited
  2. Phase 3 The Healthy Patterns Sleep Study Completed · 72 cited
  3. Phase 4 Pioglitazone as a Treatment for Lipid and Glucose Abnormalities In Patients With Schizophrenia Completed · 54 cited
  4. Phase 4 Combination Treatment Study for Memory Impairment and Depression Completed · 53 cited
  5. Phase 4 Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy Completed · 47 cited
  6. Phase 3 Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI Completed · 16 cited
Show 44 more trials
  1. Phase 4 Lithium As a Treatment to Prevent Impairment of Cognition in Elders Completed · 11 cited
  2. Phase 4 Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly Completed · 9 cited
  3. Phase 3 Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy Completed · 6 cited
  4. Phase 4 Mild Cognitive Impairment in Parkinson's Disease Completed
  5. Phase 4 Olfactory Deficits in MCI as Predictor of Improved Cognition on Donepezil Completed
  6. Phase 4 Phenytoin for Memory Impairment Secondary to Megestrol Completed
  7. Phase 4 Genomic Outcomes of Metformin Completed
  8. Phase 4 IMProving Executive Function Study Completed
  9. Phase 4 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Completed
  10. Phase 4 Body Temperature in Persons With Tetraplegia When Exposed to Cold Completed
  11. Phase 4 A 28-Week Open Label Extension Study Evaluating Safety and Tolerability of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment Completed
  12. Phase 3 Clinical Trial of Efficacy and Safety of MMH-MAP in the Treatment of Mild Cognitive Impairment in Early Recovery Stage After Ischemic Stroke Completed
  13. Phase 3 Renew NCP-5 for the Treatment of Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild Dementia of the Alzheimer's Type Completed
  14. Phase 3 Study of AGB101 in Mild Cognitive Impairment Due to Alzheimer's Disease Completed
  15. Phase 3 A Phase II Trial of Florbetapir (18F) Positron Emission Tomography (PET) Imaging in Japan of Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD) Completed
  16. Phase 3 Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects With Amnestic Mild Cognitive Impairment Who Will Convert to Clinically Probable Alzheimer's Disease Completed
  17. Phase 3 Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment Completed
  18. Phase 3 Efficacy and Safety Study of Shenwu Capsule Completed
  19. Phase 3 Hormone and Information Processing Study Completed
  20. Phase 3 Effectiveness of an Electronic Training Program for Orienting and Interpreting [18F]Flutemetamol Positron Emission Tomography (PET) Images Completed
  21. Phase 2 A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD Completed
  22. Phase 2 A Study of CST-2032 and CST-107 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Parkinson's or Alzheimer's Disease Completed
  23. Phase 2 A Longitudinal Evaluation of a Radiotracer for Use in Tau Tracking Completed
  24. Phase 2 Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment Completed
  25. Phase 2 The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial Completed
  26. Phase 2 NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment Completed
  27. Phase 2 A Study to Evaluate the Safety, Tolerability and Immunogenicity of Tau Targeted Vaccines in Participants With Early Alzheimer's Disease Completed
  28. Phase 2 Nicotinamide as an Early Alzheimer's Disease Treatment Completed
  29. Phase 2 Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive Impairment Completed
  30. Phase 2 Candesartan's Effects on Alzheimer's Disease And Related Biomarkers Completed
  31. Phase 2 Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer Completed
  32. Phase 2 Study of Nasal Insulin to Fight Forgetfulness - Device Study Completed
  33. Phase 2 Minocycline in Patients With Alzheimer's Disease Completed
  34. Phase 2 CAndesartan vs LIsinopril Effects on the BRain Completed
  35. Phase 2 Nicotine Treatment of Cognitive Decline in Down Syndrome Completed
  36. Phase 2 Pioglitazone Or Exercise to Treat Mild Cognitive Impairment (MCI) Completed
  37. Phase 2 Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study Completed
  38. Phase 2 Gulf War Illness Inflammation Reduction Trial Completed
  39. Phase 2 SNIFF Multi-Device Study 2 Completed
  40. Phase 2 Effects of Atomoxetine in Mild Cognitive Impairment Completed
  41. Phase 2 Effect of EGb761® on Brain Glucose Metabolism in Three Groups of Elderly Defined by Cognitive Functions Completed
  42. Phase 2 Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120) Completed
  43. Phase 2 SNIFF - Combo INI+EMPA Trial Completed
  44. Phase 2 Safety and Efficacy Study of Ladostigil in Mild to Moderate Probable Alzheimer's Disease Completed

Showing the 50 most-cited and recently-updated of 230 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Mild Cognitive Impairment: what the trials found

Pharmacological management of conditions associated with cognitive impairment includes the use of Donepezil, which has been evaluated for its impact on Selective Reminding Test (SRT) scores over time [20, 22]. Additionally, low-dose Haloperidol has been shown to be effective in reducing the number of days patients experience delirium 21.

Pioglitazone was evaluated for metabolic markers; results showed mixed changes in serum triglycerides, HDL, and glucose levels at three months 19.

Recent results — preliminary, needs further review

  • Time-restricted eating was associated with significant improvements in Memory Composite Rank (p<0.001), Executive Function Composite Rank (p=0.017), and Metabolic Function Composite Rank (p=0.048) 9.
  • The OneClick Social Engagement Intervention significantly improved measures of social isolation, loneliness, and quality of life in patients 18.
  • A Telerehabilitation physical activity behavioral (TPAB) intervention resulted in significant changes in average daily steps (p=0.04) 6.
  • Referral for Cognitive Stimulation Therapy was associated with a statistically significant reduction in cognitive impairment (p<0.05), though acceptance and completion rates varied 10.
  • Several other interventions are currently being investigated, including Valacyclovir hydrochloride 2, Tesamorelin 3, a computer-based multimodal mind and body approach 4, STEPS-CI 5, Computerized Cognitive Remediation of Executive Functioning 7, Brain Health Academy 8, SimpleC Wellness Platform with Social Robot Interaction 11, PEP 12, Intensive Aerobic and Resistance Exercise Program (IAREP) 13, Patient Priorities Care 14, PlanYourLifespan.org 15, PET Biomarker Disclosure 16, and HD-tDCS combined with CT 17.

For the clinician treating this condition

  • Donepezil is established as a treatment option for improving cognitive scores in relevant populations [20, 22].
  • Low-dose Haloperidol may be utilized to reduce the duration of delirium 21.
  • Time-restricted eating has shown statistically significant improvements across memory, executive function, and metabolic markers 9.

AI synthesis of 19 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Palliative Care Guideline
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Frontiers Sep 12, 2026
Dysregulated tryptophan metabolism drives neurocognitive complications in approximately 40% of patients with chronic kidney disease
Nephrology Sys. Review
Dysregulated tryptophan metabolism drives neurocognitive complications in approximately 40% of patients with chronic kidney disease Tryptophan metabolism may link kidney disease to brain fog
This narrative review explores how dysregulated tryptophan metabolism, including kynurenine and indole pathways, contributes to cognitive im…
About 40% of people with chronic kidney disease experience cognitive issues, potentially linked to how the body processes a nutrient called …
Frontiers Aug 29, 2026
Computerized cognitive training and cognitive stimulation therapy improve MMSE and MoCA scores in older adults
Primary Care & Family Medicine Meta-analysis
Computerized cognitive training and cognitive stimulation therapy improve MMSE and MoCA scores in older adults Computerized Training Shows Promise for Improving Cognitive Function
This Bayesian network meta-analysis of 35 randomized controlled trials evaluated multiple interventions for cognitive impairment in older ad…
New data from a large analysis suggests that computerized training and brain stimulation may help improve memory and thinking in older adult…
Frontiers Aug 16, 2026
Prolonged FVEP-P2 latency is associated with Alzheimer's disease and other forms of dementia
Neurology Meta-analysis
Prolonged FVEP-P2 latency is associated with Alzheimer's disease and other forms of dementia Brain Signal Delays Linked to Alzheimer's and Dementia Types
This meta-analysis of 18 comparisons involving 1,778 participants found significantly prolonged FVEP-P2 latency in patients with Alzheimer's…
A large review found that specific brain signal delays are linked to Alzheimer's disease and other forms of cognitive decline.
Frontiers Aug 10, 2026
Robot-based interventions reduce depressive and anxiety symptoms in older adults with cognitive impairment
Psychiatry Meta-analysis
Robot-based interventions reduce depressive and anxiety symptoms in older adults with cognitive impairment Robot-based Interventions Reduce Depression in Older Adults with Cognitive Impairment
This meta-analysis of 514 older adults with cognitive impairment found that robot-based interventions significantly reduced depressive sympt…
New research suggests that robot-based interventions can help reduce feelings of depression and anxiety in older adults living with cognitiv…
Aug 1, 2026
Pain assessment guidelines for cognitively impaired older adults lack practical detail
Anesthesiology & Pain Medicine Sys. Review
Pain assessment guidelines for cognitively impaired older adults lack practical detail Pain guidelines for dementia patients lack practical advice
This scoping review mapped pain assessment guidelines for hospitalized older adults with cognitive impairment. No Australian guidelines were…
A review finds most pain assessment guidelines for older adults with dementia offer little practical help for hospital staff.
Frontiers Jul 29, 2026
Frailty associated with higher odds of cognitive impairment in patients with chronic kidney disease
Nephrology Meta-analysis
Frailty associated with higher odds of cognitive impairment in patients with chronic kidney disease Frailty increases risk of cognitive issues in kidney disease patients
This meta-analysis of 129,868 patients with chronic kidney disease (CKD) found that frailty is associated with a significantly higher risk o…
People with chronic kidney disease who experience frailty are much more likely to face memory and thinking problems than those who stay robu…
Jul 25, 2026
Network meta-analysis protocol aims to rank structured exercise interventions for fall prevention in dementia
Rheumatology Meta-analysis
Network meta-analysis protocol aims to rank structured exercise interventions for fall prevention in dementia Exercise Programs May Help Prevent Falls in Seniors with Dementia
This is a protocol for a systematic review and network meta-analysis regarding structured exercise interventions for older adults with mild …
A planned review aims to determine which types of structured exercise best help older adults with memory loss stay safe and avoid falling.
Frontiers Jul 24, 2026
Bibliometric analysis identifies growing research trends and key hubs for short-chain fatty acids in cognitive impairment
Neurology Sys. Review
Bibliometric analysis identifies growing research trends and key hubs for short-chain fatty acids in cognitive impairment Mapping the Growing Research on Gut Health and Memory Loss Diseases
This systematic review provides a bibliometric analysis of 425 WoSCC and 514 Scopus records regarding short-chain fatty acids (SCFAs) and co…
Scientists are tracking how gut-related compounds might help brain health. This review maps out years of research into these important links…
Frontiers Jul 19, 2026
Multidomain lifestyle interventions provide small but statistically significant benefits for global cognition scores
Neurology Meta-analysis
Multidomain lifestyle interventions provide small but statistically significant benefits for global cognition scores Multidomain lifestyle changes may help slow signs of dementia
This meta-analysis of randomized controlled trials involving 23209 participants found that multidomain lifestyle interventions (three or mor…
Combining multiple lifestyle habits like diet and exercise can lead to small but steady improvements in brain health for those at risk of de…
medRxiv Jul 16, 2026
Sarcopenia is associated with 2.30 higher odds of cognitive impairment in Latin American adults
Geriatrics & Aging Meta-analysis
Sarcopenia is associated with 2.30 higher odds of cognitive impairment in Latin American adults Sarcopenia Linked to Higher Risk of Cognitive Impairment
This systematic review and meta-analysis of 8 studies involving 13,395 community-dwelling adults in Latin America found that sarcopenia is s…
A large review of data from Latin America shows that muscle loss in older adults is linked to a much higher risk of cognitive impairment.
Jul 6, 2026
Evaluating High Frequency Repetitive Transcranial Magnetic Stimulation for Post Stroke Cognitive Impairment
Neurology Meta-analysis
Evaluating High Frequency Repetitive Transcranial Magnetic Stimulation for Post Stroke Cognitive Impairment Magnetic brain stimulation may improve memory after a stroke
Meta-analysis results indicate that HF-rTMS significantly improves various memory functions in patients suffering from post-stroke cognitive…
A large review of data suggests that high-frequency magnetic stimulation could help improve memory for people living with post-stroke cognit…
Jul 1, 2026

Research across Cognitive Dysfunction

Related studies from across the Cognitive Dysfunction family.

Remimazolam may reduce early postoperative cognitive dysfunction risk and intraoperative opioid consumption in elderly patients
Drug Pipeline Meta-analysis
Remimazolam may reduce early postoperative cognitive dysfunction risk and intraoperative opioid consumption in elderly patients Remimazolam May Reduce Early Cognitive Risks After Surgery
This meta-analysis of 2,226 elderly surgical patients evaluated remimazolam compared to other sedatives. The analysis found that remimazolam…
A new sedative may help protect elderly patients from early cognitive issues after surgery while reducing the need for other pain medication…
Frontiers Sep 13, 2026
Higher adherence to MedDiet and DASH associated with better executive function in aging populations
Nutrition & Obesity Medicine Meta-analysis
Higher adherence to MedDiet and DASH associated with better executive function in aging populations Mediterranean and DASH diets linked to better brain health
This meta-analysis of 8 longitudinal cohorts involving 17,368 individuals in Europe and the United States found that higher adherence to the…
Specific dietary patterns like the Mediterranean and DASH diets may help protect memory and mental focus as people age.
Sep 7, 2026
Aerobic and combined physical-cognitive training programs may improve executive function and decision-making in older adults
Geriatrics & Aging Sys. Review
Aerobic and combined physical-cognitive training programs may improve executive function and decision-making in older adults Combined Physical and Cognitive Training May Improve Decision Making
This narrative review examines the impact of aerobic and combined physical-cognitive training on cognitive decline in healthy older adults. …
Combining aerobic exercise with cognitive training may improve executive functions and brain health in older adults to support better decisi…
Frontiers Aug 27, 2026
Dexmedetomidine plus esketamine may reduce postoperative delirium and injury
Pediatrics Meta-analysis
Dexmedetomidine plus esketamine may reduce postoperative delirium and injury Combined dexmedetomidine and esketamine may protect brain function after surgery
Perioperative combo of dexmedetomidine and esketamine lowers neuronal injury biomarkers and delirium risk in surgical patients.
A new analysis suggests a combination of two medications could lower the risk of confusion and protect brain health during and after surgery…
Frontiers Aug 21, 2026
Visual art therapy significantly improves global cognitive function and activities of daily living in older adults
Psychiatry Meta-analysis
Visual art therapy significantly improves global cognitive function and activities of daily living in older adults Visual art therapy improves memory and daily tasks in seniors
This meta-analysis of randomized controlled trials indicates that visual art therapy improves global cognitive function (SMD = 0.39) and act…
Engaging in visual art therapy can help older adults improve their overall brain function and perform daily activities more easily.
Frontiers Aug 19, 2026
Moderate-intensity resistance training improves cognitive performance and brain health markers in older adults
Geriatrics & Aging Sys. Review
Moderate-intensity resistance training improves cognitive performance and brain health markers in older adults Resistance Training May Boost Brain Health in Older Adults
This narrative review of 28 peer-reviewed publications synthesizes evidence on the effects of low-, moderate-, and high-intensity resistance…
Lifting weights, especially at moderate intensity, may improve memory and thinking in older adults, a review finds.
Frontiers Jul 30, 2026
Gastrodin, intranasal insulin, and cognitive training show greatest preventive effectiveness for postoperative cognitive dysfunction after cardiac surgery
Neurology Meta-analysis
Gastrodin, intranasal insulin, and cognitive training show greatest preventive effectiveness for postoperative cognitive dysfunction after cardiac surgery Insulin, Gastrodin, and Training May Protect Brain After Heart Surgery
A systematic review and Bayesian network meta-analysis of 46 RCTs (9,928 patients) ranked 20 strategies for preventing postoperative cogniti…
A review of 46 trials suggests certain drugs and cognitive training may help prevent confusion and memory loss after cardiac surgery.
Frontiers Jul 26, 2026
Shenmai and Shenfu injections may reduce postoperative cognitive dysfunction incidence following surgical procedures
Drug Pipeline Meta-analysis
Shenmai and Shenfu injections may reduce postoperative cognitive dysfunction incidence following surgical procedures Two injections may help patients recover mental clarity after surgery
This meta-analysis of 16 RCTs involving 1,199 patients indicates that Shenmai and Shenfu injections are associated with higher MMSE scores a…
New data suggests that Shenmai and Shenfu injections could help patients regain mental clarity and awareness more quickly after undergoing s…
Frontiers Jul 25, 2026
Natural compounds may alleviate anesthesia induced cognitive dysfunction through multi-target regulatory mechanisms
Drug Pipeline Sys. Review
Natural compounds may alleviate anesthesia induced cognitive dysfunction through multi-target regulatory mechanisms Natural Compounds May Help Protect Brains After Anesthesia
This systematic review evaluates 16 natural compounds, including flavonoids and polyphenols, regarding their role in mitigating anesthetic-i…
Certain natural compounds like flavonoids and polyphenols may help protect brain function from damage caused by inhalational anesthetics.
Frontiers Jul 25, 2026
Neuroinflammation as an interconnected network process regulates synaptic integrity and neuronal survival in cognitive aging
Geriatrics & Aging Sys. Review
Neuroinflammation as an interconnected network process regulates synaptic integrity and neuronal survival in cognitive aging Neuroinflammation as a Network Process in Cognitive Decline
This mini-review explores neuroinflammation as a complex, interconnected network process influencing brain health. The authors synthesize ho…
A new mini-review suggests neuroinflammation acts as an interconnected network that can either protect or harm the brain, influencing cognit…
Frontiers Jul 24, 2026
Food insecurity linked to poorer diet and higher obesity risk in older adults
Nutrition & Obesity Medicine Sys. Review
Food insecurity linked to poorer diet and higher obesity risk in older adults Food Insecurity Linked to Poorer Diet and Obesity in Older Adults
This narrative review synthesizes evidence linking food insecurity and financial hardship to poorer diet quality and higher odds of overweig…
Older adults facing food insecurity eat worse and are more likely to be obese, a review finds.
Frontiers Jun 8, 2026
Younger US men show sharp loneliness increase, older men stable, systematic review finds
Psychiatry Meta-analysis
Younger US men show sharp loneliness increase, older men stable, systematic review finds Loneliness Linked To Health Risks In Men Across The United States
This systematic review of 30 core studies on US men found no widespread epidemic of loneliness, but younger men (ages 18–29) show a sharp in…
A review of 30 studies finds loneliness in men is linked to depression, heart disease, and higher mortality, with younger men facing a sharp…
Frontiers Jun 3, 2026

Questions about Mild Cognitive Impairment

Does losing the sense of smell mean mild cognitive impairment will become dementia?

Losing your sense of smell is a warning sign that mild cognitive impairment may progress to dementia, but it does not guarantee it will happen.

Full answer →
Can brain shrinkage patterns predict when mild cognitive impairment turns into Alzheimer's disease?

Yes, specific brain shrinkage patterns, especially in the precuneus and fusiform gyrus, can help predict progression from mild cognitive impairment to Alzheimer's disease, but more research is needed.

Full answer →
Is replacing plasma with young donor blood safe for people with mild cognitive impairment?

A small pilot study found that replacing plasma with young donor blood is feasible and appears safe in the short term for people with mild cognitive impairment, but larger, longer-term studies are needed.

Full answer →
Does type 2 diabetes affect psychological health and cognitive impairment?

Yes, type 2 diabetes is linked to higher risks of depression, anxiety, and cognitive impairment, partly through the gut-brain axis and metabolic effects.

Full answer →

All Mild Cognitive Impairment Articles