Phase 1
Completed N=32
Memory Modulation by Pain During Anesthesia
Amnesia · Postoperative Pain · Anesthesia
Source: ClinicalTrials.gov NCT02515890 ↗
Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Jul 2020
Primary outcomePrimary: Memory Testing — 1.20; .56; .82; 1.18 d' score
Summary
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Memory Testing |
1.20; .56; .82; 1.18; 1.12; .55 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy adult volunteers, with normal memory and hearing, whose native language is English
Exclusion Criteria
- pregnancy
- significant memory or hearing loss
- sleep apnea
- chronic pain
- metal or electronic implants
- claustrophobia
- Currently taking: antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, sleep-aids, or pain medication
Data sourced from ClinicalTrials.gov (NCT02515890). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.