Phase 1
N=32
Memory Modulation by Pain During Anesthesia
Amnesia · Pain · Anesthesia
Bottom Line
View on ClinicalTrials.gov: NCT02515890 ↗Enrolled (actual)
32
Serious AEs
0.0%
Results posted
Jul 2020
Primary outcome: Primary: Memory Testing — 1.20; .56; .82; 1.18 d' score
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 1
- Interventions
- Dexmedetomidine (Drug); Midazolam (Drug); Peripheral nerve stimulation (Device); Ketamine (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Pittsburgh
- Primary completion
- Dec 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Memory Testing |
1.20; .56; .82; 1.18; 1.12; .55 | — |
Summary
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.
Eligibility Criteria
Inclusion Criteria
- Healthy adult volunteers, with normal memory and hearing, whose native language is English
Exclusion Criteria
- pregnancy
- significant memory or hearing loss
- sleep apnea
- chronic pain
- metal or electronic implants
- claustrophobia
- Currently taking: antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, sleep-aids, or pain medication
Data sourced from ClinicalTrials.gov (NCT02515890). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.