Phase 4
Completed N=10
Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain
Postoperative Pain · hernia · Anesthesia, Intravenous · Anesthesia, Intratracheal
Source: ClinicalTrials.gov NCT02527083 ↗
Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Dec 2025
Primary outcomePrimary: Pain Score, Chronic — 1.7; 1.5; 0; .8 score on a scale
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
Research suggests that the type of anesthesia used for surgery may affect intraoperative stress hormone levels. There is also data to support that an increased level of stress hormones leads to increased pain after surgery. The primary aim of this study is to determine the effect of anesthesia type on long term pain after hernia surgery. In this study, patients undergoing inguinal hernia repair will be randomized to an anesthetic group, either Total Intravenous Anesthesia (TIVA) maintained with propofol or Balanced Inhaled Anesthesia (BIA) maintained with sevoflurane. This will allow us to look at any differences in short and long-term pain after hernia repair depending on type of anesthesia received.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Score, Chronic |
1.7; 1.5; 0; .8; 0; 0 | — |
| SECONDARY Pain Score, Acute |
4.6; 9.0; 3.0 | — |
Eligibility Criteria
Inclusion Criteria
- All male patients undergoing herniorrhaphy surgery that requires general anesthesia.
Exclusion Criteria
- Subjects unable to communicate directly with the investigators, due to being non-English speaking, loss of hearing, or incompetence.
- A history of malignant hyperthermia, pseudocholinesterase deficiency, or other disease that prevents anesthetic randomization.
- Pain-related disorders such as fibromyalgia or other chronic pain syndromes.
- Emergency surgery.
Data sourced from ClinicalTrials.gov (NCT02527083). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.