Phase 3
N=349
Does Endometrial Injury Improve Intrauterine Insemination Outcome?
Infertility
Bottom Line
View on ClinicalTrials.gov: NCT02542280 ↗Enrolled (actual)
349
Serious AEs
0.0%
Results posted
Jan 2016
Primary outcome: Primary: Chemical Pregnancy Rate — 40; 19 participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 3
- Interventions
- endometrial injury. (Procedure); intrauterine insemination (Procedure); ovarian stimulation (Drug)
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Ain Shams Maternity Hospital
- Primary completion
- Jul 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Chemical Pregnancy Rate |
40; 19 | — |
| PRIMARY Clinical Pregnancy Rate |
32; 13 | — |
Summary
The investigator suggests that local endometrial injury using pipelle catheter performed in the follicular phase (cycle day 5, 6 or 7) of the stimulation cycle may improve the pregnancy rates among patients undergoing intrauterine insemination.
Eligibility Criteria
Inclusion Criteria
- 18 - 38 years.
- patent fallopian tunes.
- mild male factor.
- anovulation.
- unexplained infertility.
Exclusion Criteria
- indications for ICSI.
- evidence of pelvic inflammatory disease.
Data sourced from ClinicalTrials.gov (NCT02542280). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.