Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.

Key Inclusion Criteria

• Possess the capacity to provide written informed consent which must be obtained before any assessment is performed.
• Currently hospitalized for ADHF. Patients with a diagnosis of acute heart failure had to have symptoms and signs of fluid overload (i.e. jugular venous distention, edema or rales on auscultation or pulmonary congestion on chest x-ray) at time of hospitalization.
• Eligible patients will be randomized no earlier than 24 hours and up to ten days after presentation while still hospitalized as long as meet the following definition of stable status:
• SBP ≥100mm Hg for the preceding 6 hours prior to randomization; no symptomatic hypotension
• No increase (intensification) in i.v. diuretic dose within last 6 hours prior to randomization
• No i.v. inotropic drugs for 24 hours prior to randomization
• No i.v. vasodilators including nitrates within last 6 hours prior to randomization
• LVEF ≤40% within the past 6 months (including current hospitalization) using echocardiography, multi gated acquisition scan (MUGA), CT scanning, MRI or ventricular angiography, provided no subsequent study documented an EF of >40%.
• Elevated NT-proBNP ≥ 1600pg/mL OR BNP ≥400 pg/mL during current hospitalization.

Key Exclusion Criteria

• Currently taking sacubitril/valsartan tablets or any use within the past 30 days.
• Enrollment in any other clinical trial involving an investigational agent or investigational device.
• History of hypersensitivity, known or suspected contraindications, or intolerance to any of the study drugs, including ACEIs, ARBs, or Sacubitril (NEP inhibitor).
• Patients with a known history of angioedema related to previous ACE inhibitor or ARB therapy.
• Requirement of treatment with both ACE inhibitor and ARB.
• eGFR 5.2 mEq/L at screening.
• Known hepatic impairment (as evidenced by total bilirubin > 3 mg/dL, or increased ammonia levels, if performed), or history of cirrhosis with evidence of portal hypertension such as varices
• Acute coronary syndrome, stroke, transient ischemic attack; cardiac, carotid or other major CV surgery; percutaneous coronary intervention (PCI) or carotid angioplasty, within one month prior to Visit 1.
• Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test.
• Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, including women whose career, lifestyle, or sexual orientation precludes intercourse with a male partner and women whose partners have been sterilized by vasectomy or other means, UNLESS they are using two birth control methods.