N/A
N=18
A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism
Type 2 Diabetes Mellitus
Bottom Line
View on ClinicalTrials.gov: NCT02563834 ↗Enrolled (actual)
18
Serious AEs
0.0%
Results posted
Aug 2016
Primary outcome: Primary: Myocardial Fatty Acid Uptake Rate — 18.492; 2.123; 36.005; 7.8 umol/min/100g
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- thiapalmitate tracer (Drug); Saline (Drug); Insulin (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Indiana University
- Primary completion
- Jun 2009
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Myocardial Fatty Acid Uptake Rate |
18.492; 2.123; 36.005; 7.8 | — |
| SECONDARY Myocardial Oxidation Rate |
15.006; 19.847; 17.381; 22.940 | — |
| SECONDARY Myocardial Perfusion Rate |
39.3; 46.5; 44.2; 49.4 | — |
Summary
Studies of myocardial fuel selection using a novel palmitate-based PET probe
Eligibility Criteria
Inclusion Criteria
- Lean:
- BMI 25 kg/m2
- previously diagnosed type 2 diabetes mellitus
- on oral and/or injected insulin treatment.
Exclusion Criteria
- Lean:
*Use of any chronic medications
- Type 2 diabetes mellitus
- known microvascular disease
- known coronary or other macro vascular disease
- use of PPARgamma class antidiabetic agents within 6 months
Data sourced from ClinicalTrials.gov (NCT02563834). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.