N/A Completed N=823 Randomized Single-blind Treatment

Weight Loss and Exercise for Communities With Arthritis in North Carolina

Osteoarthritis

Source: ClinicalTrials.gov NCT02577549 ↗

Enrolled (actual)

823

Serious AEs

19.8%

Results posted

Mar 2023

Primary outcomePrimary: Knee Pain — 5.0; 5.5 score on a scale

Summary

This study aims to develop and demonstrate the effectiveness of a systematic, practical, cost-effective diet-induced weight loss and exercise intervention in both urban and rural communities that can reduce pain and improve other clinical outcomes in knee OA patients. This pragmatic community-based trial will determine if the investigators previous findings translate to real-world settings and will address common concerns about barriers to effectiveness/ implementation.

Outcome Measures

Outcome	Result	p-value
PRIMARY Knee Pain	5.0; 5.5	—
SECONDARY Function	16.5; 19.8	—
SECONDARY Health Related Quality of Life (SF-36) Physical Subscale	41.4; 37.6	—
SECONDARY Mobility (Six Minute Walk)	419; 376	—

Eligibility Criteria

Inclusion Criteria

age ≥ 50
Knee Pain plus American College of Rheumatology (ACR) Criteria for Knee Osteoarthritis
BMI = 27 ≥ kg/m2

Exclusion Criteria

Significant co-morbid disease that would threaten safety or impair ability to participate in interventions or testing (Blindness; Type 1 diabetes; Severe coronary artery disease)
Not sufficiently overweight or obese, BMI 2 month during the next 18 months; Unwilling to change eating or physical activity habits; Unwilling to discontinue pain medication use for 3 days prior to testing visit)
Age, age < 50
Other conditions that may prohibit the effective delivery of the intervention (Unable to provide own transportation to exercise center; Unable to read or write)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02577549). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.