Research across Arthritis
Related studies from across the Arthritis family.
Questions about Osteoarthritis
How long do knee implants last in patients under 50?
For patients under 50, knee implants (total knee arthroplasty) show 87% survival at 10+ years, with aseptic loosening as the main reason for revision.
Full answer →Can engineered exosomes be used to treat osteoarthritis?
Yes, early research shows engineered exosomes can target cartilage, reduce inflammation, and promote repair in osteoarthritis, but human trials are still needed.
Full answer →Which genes are linked to osteoarthritis in meniscus and cartilage?
Genes linked to osteoarthritis in meniscus and cartilage include 27 meniscus-specific, 28 shared, and 20 cartilage-specific causal genes, such as VEGFA and CLEC18A, identified through genomic analysis.
Full answer →What role do exosomal non-coding RNAs play in osteoarthritis?
Exosomal non-coding RNAs regulate osteoarthritis by controlling inflammation, cartilage breakdown, and joint cell communication, and show promise as biomarkers and therapies.
Full answer →All Osteoarthritis Articles
- Coumarins and derivatives may protect musculoskeletal health by modulating inflammatory and oxidative mediators
- Gut microbiota-targeted interventions reduce pain and function scores in patients with osteoarthritis
- Immune signaling and bidirectional neuropeptide release drive nociceptor sensitization in osteoarthritis pain
- Therapeutic extracellular vesicles may curb inflammation and restore mitochondrial quality in osteoarthritis
- Icariin improves pain and cartilage scores in murine osteoarthritis, meta-analysis finds
- Interactive remote rehabilitation shows no significant advantage over conventional rehabilitation for post-TKA patients
- Multi-trait genome-wide association studies identify 66 novel genetic associations in osteoarthritis using the Trident framework
- Inflammaging and immunosenescence emerge as key mechanistic axes in osteoarthritis pathogenesis
- Exosomes are safe for knee osteoarthritis but show no superiority over placebo in one trial
- Telemedicine modalities may achieve comparable outcomes to conventional follow-up for uncomplicated total joint arthroplasty
- Mechanical loading induces innate immune reprogramming and mitochondrial danger signals in osteoarthritis models
- Ion channels and signaling pathways form a mechanobiological-immunological framework for osteoarthritis progression
- No genetic loci reached genome-wide significance for inpatient opioid exposure after joint arthroplasty
- Epigenetic regulation provides a framework for understanding disease heterogeneity and potential precision therapies in osteoarthritis
- Opioids provide clinically important pain relief for short durations but lack long-term efficacy in osteoarthritis
- Metabolic reprogramming of chondrocytes through impaired oxidative phosphorylation contributes to articular cartilage collapse
- Gut microbiota dysbiosis linked to osteoarthritis pathology in preclinical and human studies
- Chronic ACL deficiency increases risk of moderate to severe arthritis compared to reconstruction
- Peripheral mechanisms like proton-sensing channels and neurovascular remodeling contribute to pain in osteoarthritis
- Circadian misalignment associated with increased risk of osteoporosis, sarcopenia, and osteoarthritis
- NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
- Cartilage Thickness Score shows higher values in future knee osteoarthritis cases in a cohort study
- Patellar resurfacing and nonresurfacing show similar 5-year outcomes in total knee arthroplasty
- Gut microbiome metabolites regulate bone health via SCFAs, bile acids, and tryptophan pathways
- Umbrella review suggests curcumin may offer comparable efficacy and better tolerability than NSAIDs for osteoarthritis
- Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
- Systematic review of Dendrobium phenanthrene bioactivity across multiple disease models
- Systematic review and meta-analysis of olive-derived compounds for osteoarthritis pain
- Total hip arthroplasty with rehabilitation improves WOMAC and HHS scores versus conservative exercise in hip osteoarthritis
- Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data
- Narrative review explores exosomal non-coding RNAs in osteoarthritis pathogenesis and therapy
- Intra-articular adipose-derived cell therapies reduce pain and improve function in knee osteoarthritis without serious adverse events
- Genomic analysis identifies tissue-specific causal genes for osteoarthritis in meniscus and cartilage
- Narrative review explores engineered exosomes for bone disorders, notes translational challenges
- Meta-analysis finds 87% implant survivorship after 10 years in patients under 50 undergoing TKA
- Memantine reduces opioid use but not pain in knee osteoarthritis patients after surgery
- Medial Unicompartmental Knee Arthroplasty Shows Small Advantages Over Total Knee Arthroplasty in Severe Anteromedial Knee Osteoarthritis
- Osteoarthritis diagnosis not independently linked to recurrent falls in OAI cohort study
- Systematic review links gut microbiota dysbiosis to CKD-MBD, RA, OA, and OP pathogenesis
- Insurance delays in Indonesia impair functional recovery after total knee arthroplasty
- Personalized nutrition and behavioral correction address feline obesity and associated comorbidities like diabetes and osteoarthritis
- Systemic inflammation mediates links between sleep, obesity, and musculoskeletal pain but not consistently for psychological factors
- Weight loss >5% linked to slower cartilage thinning in knee osteoarthritis over 2 years
- Otago Exercise Program improves knee function and mobility after total knee arthroplasty in meta-analysis
- Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA
- Long-term bilateral THA study finds no osteolysis with ceramic or HXLPE bearings in patients under 65
- Denosumab showed no effect on periprosthetic bone density five years after uncemented total hip arthroplasty
- Narrative review suggests omega-3 PUFAs may benefit musculoskeletal health and sports recovery
- Meta-analysis finds no clinically significant outcome differences with postoperative glenoid retroversion ≥15° after aTSA