Narrative review explores exosomal non-coding RNAs in osteoarthritis pathogenesis and therapy
Tiny Messengers in Your Joints Could Change Osteoarthritis Care
This narrative review summarizes the role of exosomal non-coding RNAs in osteoarthritis. It discusses their involvement in disease pathogene…
Scientists are learning how to use your body’s own tiny messengers to calm inflamed joints and potentially slow osteoarthritis.
Genomic analysis identifies tissue-specific causal genes for osteoarthritis in meniscus and cartilage.
Genetic study links specific genes to knee osteoarthritis in meniscus and cartilage
This research article uses genomic analysis on human meniscus and cartilage tissue to identify genetic associations with osteoarthritis. It …
Researchers identified 75 genes tied to osteoarthritis risk in knee tissues, highlighting tissue-specific genetic patterns that could guide …
Cartilage Thickness Score shows higher values in future knee osteoarthritis cases in a cohort study.
New cartilage score predicts knee osteoarthritis onset and progression in study cohorts
This observational cohort study in the Osteoarthritis Initiative found that the Cartilage Thickness Score was higher in individuals who late…
A new cartilage score predicts who will develop knee osteoarthritis or need a replacement before symptoms appear.
Meta-analysis finds 87% implant survivorship after 10 years in patients under 50 undergoing TKA
Young Knee Pain Has a New Solution
This systematic review and meta-analysis examined 17,705 patients aged less than 50 years undergoing total knee arthroplasty (TKA) with a me…
Getting a new knee joint can give young adults the freedom to move again without pain.
Narrative review explores engineered exosomes for bone disorders, notes translational challenges
Tiny Cargo Ships Could Fix Broken Bones
This narrative review examines engineered exosomes as potential therapeutics for osteoarthritis, osteoporosis, fracture healing, and other b…
Tiny cargo ships called exosomes can deliver medicine directly to broken bones and worn joints to help them heal without hurting healthy tis…
Systematic review links gut microbiota dysbiosis to CKD-MBD, RA, OA, and OP pathogenesis.
Your gut holds the key to your bone health.
This systematic review examines the role of gut microbiota dysbiosis in chronic kidney disease-mineral and bone disorder (CKD-MBD), rheumato…
Gut bacteria directly influence bone strength and kidney health, yet current treatments ignore the digestive system where the real problem s…
Osteoarthritis diagnosis not independently linked to recurrent falls in OAI cohort study
Your Mood May Matter More Than Your Joints for Fall Risk
A retrospective cohort study of 4427 Osteoarthritis Initiative participants found that a new OA diagnosis was not independently associated w…
Older adults with knee or hip arthritis who feel down fall more often, and the emotional side of health may be the real driver.
Personalized nutrition and behavioral correction address feline obesity and associated comorbidities like diabetes and osteoarthritis.
Review finds personalized nutrition and exercise help manage cat obesity and related health issues
This systematic review evaluated determinants, diagnosis, pathophysiology, and management of obesity in domestic cats. Overweight and obesit…
Personalized nutrition and exercise plans help manage cat obesity, a common disorder that raises risks for diabetes and other serious health…
Systemic inflammation mediates links between sleep, obesity, and musculoskeletal pain but not consistently for psychological factors.
Systemic inflammation links sleep and obesity to pain, but psychological factors differ
This systematic review analyzed twenty-one articles examining systemic inflammation as a mediator between lifestyle or psychological factors…
Systemic inflammation connects sleep problems and obesity to pain, but psychological factors appear to interact differently rather than acti…
Otago Exercise Program improves knee function and mobility after total knee arthroplasty in meta-analysis
Otago Exercise Program Shows Promise for Recovery After Knee Replacement Surgery
A systematic review and meta-analysis of randomized controlled trials involving 1,088 patients undergoing total knee arthroplasty found that…
A structured exercise program may improve knee function and balance better than conventional rehab after knee replacement surgery, based on …
Denosumab showed no effect on periprosthetic bone density five years after uncemented total hip arthroplasty.
Denosumab showed no benefit for bone density five years after hip replacement surgery.
This secondary exploratory analysis of a phase-2 randomized controlled trial evaluated denosumab in 54 non-osteoporotic patients undergoing …
Five years after hip surgery, bone density declined for everyone regardless of whether patients took the drug denosumab or a placebo.
Narrative review suggests omega-3 PUFAs may benefit musculoskeletal health and sports recovery
Can omega-3 supplements help with bone health, joint pain, and muscle recovery?
A narrative review consolidating fundamental science and clinical trials suggests omega-3 polyunsaturated fatty acid (PUFA) supplementation …
Omega-3 supplements may improve bone markers, ease osteoarthritis pain, and help athletes recover faster by reducing inflammation and suppor…