N/A
N=200
Trial Comparing Transversus Abdominis Plane Block Versus Epidural Anesthesia for Pain Management in Colorectal Surgery
Colon Cancer · Rectal Cancer · Colonic Diverticulosis
Bottom Line
View on ClinicalTrials.gov: NCT02591407 ↗Enrolled (actual)
200
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcome: Primary: Post-operative Mean Numeric Pain Scale. — 2.12; 2.32 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- TAP Block (Procedure); Continuous Epidural Analgesia (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Trinity Health Michigan
- Primary completion
- Dec 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Post-operative Mean Numeric Pain Scale. |
2.12; 2.32 | — |
| PRIMARY Overall Benefits of Analgesia Score (OBAS) |
0.48; 0.37 | — |
| SECONDARY Patient Use of Narcotic Analgesia Post-op Day 0 |
80.20; 54.64 | — |
| SECONDARY Patient Use of Narcotic Analgesia Post-operative Day 0 |
27.55; 54.64 | — |
| SECONDARY Patient Use of Narcotic Analgesia Post-operative Day 3 |
0.34; 0.22 | — |
| SECONDARY Patient Use of Narcotic Analgesia Post-operative Day 1 |
71; 13.34 | — |
| SECONDARY Patient Use of Narcotic Analgesia Post-operative Day 2 |
3.11; 2.61 | — |
Summary
The primary outcome for this study is the Numeric Pain Score (NPS) for elective patients undergoing elective colorectal surgery that have been randomized to transversus abdominis plane block or epidural anesthesia for the management of perioperative pain in elective colorectal surgery.
Eligibility Criteria
Inclusion Criteria
- Patients undergoing elective open and minimally invasive (laparoscopic and robotic) colon and rectal surgery for colorectal neoplasia, diverticulitis, and other diseases of the colon and rectum;
- Surgical procedure either through standard open or minimal invasive approach (laparoscopic or robotic);
- Patients > 18 years of age;
- Able to provide informed written consent
- Patients capable of completing questionnaires at the time of consent
Exclusion Criteria
- Documented allergic reaction to morphine, hydromorphone, lidocaine, bupivicaine and/or fentanyl;
- Contra-indication to placement of epidural catheter (spinal stenosis, spinal fusion, elevated International Normalized Ratio (INR), anticoagulation, patient refusal, etc) or TAP block (patient refusal);
- Urgent or emergent surgery precluding epidural catheter placement or TAP block;
- Systemic Infection contraindicating epidural catheter placement or TAP block;
- Unwillingness to participate in follow up assessments;
- Prisoners
- Pregnant women
Data sourced from ClinicalTrials.gov (NCT02591407). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.