N/A N=22 Randomized Double-blind Treatment

Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment

Mild Cognitive Impairment

Bottom Line

View on ClinicalTrials.gov: NCT02596906 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2020

Primary outcome: Primary: Change From Baseline in California Verbal Learning Task Score — 3.04; 5.17; 4.22; 7.04 score on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: tDCS (Device); Sham tDCS (Device)
Age: Adult, Older Adult · 50+ yrs
Sex: All
Sponsor: The University of Texas at Dallas
Primary completion: Jan 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Change From Baseline in California Verbal Learning Task Score	3.04; 5.17; 4.22; 7.04	—
SECONDARY Regional Brain Blood Flow Change Immediately After 1 Month of Cognitive Training and tDCS Brain Stimulation	0.19; -0.12	—

Summary

Individuals aged 55 and older may experience negative effects of cognitive decline. The proposed research seeks to evaluate the benefits of different types of interventions: reasoning training following transcranial direct current stimulation (tDCS) and reasoning training following sham transcranial direct current stimulation (tDCS) on frontal- lobe mediated cognitive measures of executive control in adults with memory complaints, in the absence of dementia.

Eligibility Criteria

Inclusion Criteria

Safely have an MRI
Cognitive complaints in the absence of dementia
Participate in tasks involving motor abilities such as use of at least one arm and hand
Read, speak, and comprehend English
50-80 years of age
Comprehend simple instructions, perform tasks, and take part in intervention

Exclusion Criteria

Not proficient in reading, comprehending, or speaking English
Individuals who have any significant health, neurological, or psychiatric illness, or history of substance abuse
Individuals with any MR contraindications (i.e., non-removable metal within/on the body)
Individuals taking medications which are contraindicatory for the tDCS procedure
Individuals who are left-handed
Not proficient in reading, comprehending, and speaking English
Females who are not post-menopausal
Pre-existing cerebral palsy, autism, epilepsy, schizophrenia, pervasive developmental disorder, thyroid diseases, diabetes, claustrophobia, non-correctable vision problems, major depression, psychosis, active behavioral disorder, or uncontrolled epilepsy.
Women who are pregnant

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02596906). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.