Phase 4
Completed N=70
Efficacy of Corifollitropin Alfa in Obese Women in Terms of Clinical and Molecular Parameters of IVF Success
Source: ClinicalTrials.gov NCT02606500 ↗Enrolled (actual)
70
Serious AEs
0.0%
Results posted
Nov 2018
Primary outcomePrimary: Number of Oocytes Retrieved Per Patient — 11.3; 12.4 Oocytes — p=0.9
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The aim of the present study is to determine, whether clinical efficacy of 150 mcg of Corifollitropin alfa is the same in normal weighing and obese women. Furthermore, investigators want to determine whether oocytes retrieved from normal weighing and obese women, after COH using 150 mcg of Corifollitropin alfa, are of same quality on the molecular level.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Oocytes Retrieved Per Patient |
11.3; 12.4 | 0.9 |
| PRIMARY Number of Mature Oocytes |
269; 319 | 0.5 |
| PRIMARY Number of Fertilized Oocytes |
206; 207 | 0.3 |
| PRIMARY Number of Frozen Embryos |
45; 49 | 0.9 |
| PRIMARY Biochemical Pregnancy Rate |
18; 18 | 0.4 |
| SECONDARY Real-time PCR Analysis of Genes That Were Proposed as Biomarkers of Oocyte Quality to Determine Effect of Corifollitropin Alpha on Oocyte Quality on Molecular Level |
2.52; 1.31; 1.49; 0.63; 0.83; 0.61 | — |
Eligibility Criteria
Inclusion Criteria
- BMI > 30 kg/m2
- BMI 18.5-24.9 kg/m2
Exclusion Criteria
- polycystic ovary syndrome, severely abnormal sperm parameters, and age > 38 years
Data sourced from ClinicalTrials.gov (NCT02606500). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.