Phase 3
Completed N=644
Efficacy and Safety of Vedolizumab Subcutaneous (SC) as Maintenance Therapy in Crohn's Disease (CD)
Source: ClinicalTrials.gov NCT02611817 ↗Enrolled (actual)
644
Serious AEs
11.8%
Results posted
Jun 2020
Primary outcomePrimary: Percentage of Participants Achieving Clinical Remission at Week 52 — 34.3; 48.0 percentage of participants — p=0.008
◆ Published Evidence
Emerging
3citations · ~2 / year
Efficacy of vedolizumab during intravenous induction therapy in ulcerative colitis and Crohn's disease: post hoc analysis of patient-reported outcomes from the VISIBLE 1 and 2 studies.
Summary
The purpose of this study is to assess the effect of vedolizumab subcutaneous (vedolizumab SC) as maintenance treatment in participants with moderately to severely active CD who achieved clinical response following administration of vedolizumab intravenous (vedolizumab IV) induction therapy.
Linked Publications
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Efficacy of vedolizumab during intravenous induction therapy in ulcerative colitis and Crohn's disease: post hoc analysis of patient-reported outcomes from the VISIBLE 1 and 2 studies.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Participants Achieving Clinical Remission at Week 52 |
34.3; 48.0 | 0.008 sig |
| SECONDARY Percentage of Participants Achieving Enhanced Clinical Response at Week 52 |
44.8; 52.0 | 0.167 |
| SECONDARY Percentage of Participants Achieving Corticosteroid-free Remission at Week 52 |
18.2; 45.3 | 0.002 sig |
| SECONDARY Percentage of TNF-alpha Antagonist Naive Participants Achieving Clinical Remission at Week 52 |
42.9; 48.6 | 0.591 |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of CD established at least 3 months prior to screening by clinical and endoscopic evidence corroborated by a histopathology report.
- Moderately to severely active CD as determined by a CDAI score of 220 to 450 and 1 of the following:
- C-reactive protein (CRP) level greater than (>) 2.87 milligram per liter (mg/L) OR
- Ileocolonoscopy with photographic documentation of a minimum of 3 nonanastomotic ulcerations (each >0.5 centimeter [cm] in diameter) or 10 aphthous ulcerations (involving a minimum of 10 contiguous cm of intestine) consistent with CD OR
- Fecal calprotectin >250 microgram per gram (mcg/g) stool during the screening period in conjunction with computed tomography enterography (CTE), magnetic resonance enterography (MRE), contrast-enhanced small bowel radiography, or wireless capsule endoscopy revealing CD ulcerations (aphthae not sufficient).
- CD involvement of the ileum and/or colon, at a minimum.
- Inadequate response with, loss of response to, or intolerance to corticosteroids, immunomodulators, or Tumor necrosis factor-alpha (TNF-α) antagonists.
Exclusion Criteria
- Evidence of abdominal abscess at Screening.
- Extensive colonic resection, subtotal or total colectomy.
- History of >3 small bowel resections or diagnosis of short bowel syndrome.
- Ileostomy, colostomy, or known fixed symptomatic stenosis of the intestine.
- Prior exposure to investigational or approved non-biologic therapies (example, cyclosporine, tacrolimus, thalidomide, or tofacitinib) for the treatment of underlying disease within 30 days or 5 half-lives of screening (whichever is longer).
- Prior exposure to any investigational or approved biologic or biosimilar agent within 60 days or 5 half-lives of screening (whichever is longer).
- Prior exposure to vedolizumab.
- Surgical intervention for CD required at any time during the study.
- History or evidence of adenomatous colonic polyps that have not been removed, or of colonic mucosal dysplasia.
- Suspected or confirmed diagnosis of ulcerative colitis, indeterminate colitis, ischaemic colitis, radiation colitis, diverticular disease associated with colitis, or microscopic colitis.
- Active infections.
- Chronic hepatitis B virus (HBV) or C (HCV) infection, tuberculosis (TB) (active or latent), or congenital or acquired immunodeficiency. HBV immune participants (that is, being hepatitis B surface antigen [HBsAg] negative and hepatitis B antibody positive) may, however, be included.
- History of any major neurological disorders, including stroke, multiple sclerosis, brain tumor, or neurodegenerative disease.
Data sourced from ClinicalTrials.gov (NCT02611817) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.