N/A
Completed N=23
Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine
Blood Levels of Buffered vs Non-buffered Lidocaine · Anesthetics, Local
Source: ClinicalTrials.gov NCT02620683 ↗
Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Jan 2018
Primary outcomePrimary: Lidocaine Blood Levels 30 Minutes Post Injection — 7.9; 15.8 ug/L — p=0.006
Summary
Anecdotal reports suggest buffering lidocaine with epinephrine just before intraoral injection reduces time of onset, results in a deeper anesthetic effect, without the "sting" with injection from a low pH. Additional data are needed to establish clinical important outcomes such as the peak blood level of lidocaine as compared to the non-buffered drug combination.
Clinical pilot studies are proposed as the start of a series of investigations to support or modify the use of the buffered anesthetic for intraoral procedures.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Lidocaine Blood Levels 30 Minutes Post Injection |
7.9; 15.8 | 0.006 sig |
| SECONDARY Pain Intensity Scores |
2.6; 3.0 | 0.096 |
| SECONDARY Number of Minutes to Anesthesia Symptoms of Lower Lip |
10.2; 13.7 | 0.23 |
| SECONDARY Topical Anesthesia Effect Contralateral Lower Lip |
— | — |
Eligibility Criteria
Inclusion Criteria
- Age 18-30 years
- ASA I
- Willingness to complete QOL instrument
- Willingness to participate in two sessions
Exclusion Criteria
- Allergy to lidocaine class of anesthetic drugs
- Local anesthetic drug use in past week
- Current symptoms teeth or oral mucosa
Data sourced from ClinicalTrials.gov (NCT02620683). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.