N/A N=23 Clinical Outcomes of Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine
Anesthesia
Primary: Mean Time to Pulpal Response After Mandibular Molar Anesthesia — 99; 98 Minutes — p=0.74
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=24 Clinical Outcomes Maxilla: Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine
Anesthesia
Primary: Mean Time to Pulpal Response After Maxillary Molar Anesthesia — 98.8; 84.5 minutes
N/A N=23 Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine
Blood Levels of Buffered vs Non-buffered Lidocaine · Anesthetics, Local
Primary: Lidocaine Blood Levels 30 Minutes Post Injection — 7.9; 15.8 ug/L — p=0.006
Phase 4 N=24 Clinical Outcomes Mandible: Buffered 1% vs. Non-Buffered 1% Lidocaine
Anesthesia, Local
Primary: Mean Time to Pulpal Response After Mandibular Molar Anesthesia — 100; 106 minutes
Phase 4 N=64 Buffered Lidocaine in the Pediatric Dental Patient
Pediatric Dentistry
Primary: Patient Reported Pain Perception — 3.52; 3.48 units on a scale
N/A N=88 Efficacy of Buffered Lidocaine in Patients With Facial Swelling
Orofacial Swelling
Primary: Pain Measurement as Assessed on a Heft-Parker 170 mm Visual Analog Scale — 69.3; 59.2 units on a scale
Phase 4 N=150 Local Anesthetics for Pain Reduction Prior to IV Line Placement
Pain · Local Anesthesia for Peripheral Intravenous Catheterization
Primary: Pain Score Following Anesthetic Administration — 2.81; 1.64; 2.05 units on a scale
Phase 2 N=56 Buffered Lidocaine for Loop Electrosurgical Excision Procedures (LEEPs)
Uterine Cervical Dysplasia
Primary: Injection Pain Score (Mean) — 25; 19 units on a scale — p=.13
Phase 4 N=98 Buffered Lidocaine in Paracervical Blocks
Pain
Primary: Injection Pain — 44.5; 30 units on a scale
N/A N=100 Effect of Buffered Numbing Solution on Patients With Toothaches
Irreversible Pulpitis (Toothache)
Primary: Percent of Patients With Successful Anesthesia (% of Patients Able to Have Treatment Without Additional Anesthesia) — 16; 20 Participants
Phase 4 N=26 Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years
Anesthesia, Local · Pain
Primary: Mean Pain Scores Following Injection — 3.0; 3.3 score on a scale — p=0.38
Phase 4 N=20 Buffered Local Anesthetic
Dental Pain
Primary: Pain Score as Measured by the Behavior Pain Scale — 2.24; 2.61 score on a scale — p=0.005
N/A N=19 Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery
Basal Cell Carcinoma · Squamous Cell Carcinoma
Primary: The Number of Subjects With Detectable Serum Lidocaine Concentrations (<0.1 ug/mL) at Each Blood Draw. — 0; 1; 0; 2 Participants
Phase 4 N=20 Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
Pain
Primary: Participant Pain Experience After Administration of Local Anesthesia to Numb the Gums and Teeth During Dental Treatment — 43; 33.1; 7.3; 9.8 units on a scale — p=0.23
Phase 4 N=86 Reducing Pain of Lidocaine Injection
Pain of Anesthesia at Breast Biopsy
Primary: Pain — 1.19; 0.56 units on a scale
Phase 4 N=80 Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Anesthetic Effectiveness
Primary: Number of Participants Achieving Pulpal Anesthesia. — 52; 57 Participants
Phase 4 N=40 Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
Symptomatic Irreversible Pulpitis
Primary: VAS Scores as Measures of Profoundness of Pulpal Anesthesia — 3.1; 1.2 Score on a scale
Phase 4 N=481 Comparison of Two Lidocaine Administration Techniques
Pain
Primary: Pain Assessment: Overall — 15.3; 19.0 units on a scale
N/A N=30 Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur® After Cesarean Delivery
Epidural Analgesia, Obstetric
Primary: Maximum Plasma Concentration (Cmax) of Extended Release Epidural Morphine (EREM) — 11.1; 8.3 ng/mL
Phase 4 N=23 Pharmacokinetics of Lidocaine in Healthy Adults
Healthy
Primary: Measurement of Maximum Serum Concentration of Lidocaine (Cmax) — 113.95; 123.54; 706.15 ng/ml
Phase 3 N=32 Subcutaneous Lidocaine For Cancer-Related Pain
Cancer-related Pain
Primary: Number of Participants With Reduction in Worst Pain Intensity or Reduction in 24hr Opioid Dose of at Least 30% Without Worsening of Pain Scores — 1; 2; 2; 1 Participants
Phase 4 N=48 Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block
Neuromuscular Block
Primary: Latency — 139.70; 151.30; 147.80 seconds — p=0.9651
N/A N=91 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics
Methemoglobinemia
Primary: Peak Methemoglobin Blood Levels — 3.55; 1.63; 1.60 percentage of methemoglobin in blood — p=<.001
Phase 4 N=50 Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain
Injections, Intravenous
Primary: Patient Expression of Pain — 0.76; 0.04 units on a scale
Phase 4 N=36 Continuous Lidocaine Infusion for Management of Perioperative Burn Pain
Thermal Burns
Primary: Narcotic Consumption (Measured in mg/kg Narcotic Consumption) — 57.5; 67.75 mg/kg narcotic consumption
Phase 2 N=32 Lidocaine as an Endotracheal Tube (ETT) Cuff Media
Cardiac Disease
Primary: Total Sedation Requirements — 325; 1158 milligrams
Early Phase 1 N=70 Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery
Surgical Anesthesia, Cesarean Section
Primary: The Onset Time to Surgical Anesthesia — 558; 655 seconds — p=0.10
Phase 4 N=12 Determination of the Duration of Action of a Lidocaine and a Bupivacaine Digital Nerve Block in Human Volunteers
Onset and Duration of a Digital Nerve Block
Primary: The Change in the Average Finger Temperature From Baseline to Post-intervention. — -1.35; 0.93 degrees centigrade
Phase 4 N=32 Intravenous Lidocaine Versus Morphine for Severe Pain in the ED
Pain
Primary: Pain Score (NRS 0-10) — 5.1; 4.2 units on a scale
N/A N=20 Effect of Local Anaesthetic Dilution on the Characteristics of Ultrasound Guided Axillary Brachial Plexus Block
Brachial Plexus Blockade
Primary: Onset of Axillary Block — 8.75; 6.25 minutes — p=0.03