N/A
Completed N=38
Aerobic Exercise for Cognition in Schizophrenia
Source: ClinicalTrials.gov NCT02621983 ↗Enrolled (actual)
38
Serious AEs
10.5%
Results posted
Oct 2019
Primary outcomePrimary: Change in Cognitive Function, Assessed by Scores on the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) — 24.909; 31.333; 27.727; 32.833 T-score
Summary
This study will evaluate the ability of aerobic exercise (AE) to improve cognition in people with schizophrenia. Participants will be randomly assigned to one of two interventions: (1) aerobic exercise class (stationary bicycle, or "spin" class) for up to 45 minutes three times per week for 12 weeks, or (2) balance and stretching class for up to 45 minutes three times per week for 12 weeks.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Cognitive Function, Assessed by Scores on the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) |
24.909; 31.333; 27.727; 32.833 | — |
| SECONDARY Change in Functional Ability |
58.55; 67.83; 60.64; 64.16 | — |
| SECONDARY Change in MCCB Scores |
24.78; 31.33; 29.33; 29.5 | — |
| SECONDARY Change in Scores on the University of California San Diego Performance-Based Skills Assessment (UPSA) |
57.66; 67.83; 64.33; 67.33 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of schizophrenia or schizoaffective disorder
- maintained on stable doses of outpatient psychiatric medications for at least 30 days
- compliant with outpatient follow-up
- have a stable place to live
- access to transportation to the hospital
- doing less than 20 minutes per week of regular physical activity in the past month
Exclusion Criteria
- Bipolar disorder;
- active substance dependence within the prior 30 days
- more than 2 psychiatric admissions within the prior six months
- known HIV infection or AIDS
- history of traumatic brain injury
- current seizure disorder
- Alzheimer's disease or other dementia
- clinical history of mild cognitive impairment
- Parkinson's disease
- other current clinically significant neurological disease
- unstable medical condition that would be expected to interfere with fitness training
- significant hearing or visual impairment
Data sourced from ClinicalTrials.gov (NCT02621983). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.