N/A N=51 Randomized Treatment

Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs

Hypotension · Anesthesia

Bottom Line

View on ClinicalTrials.gov: NCT02624050 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Mar 2019

Primary outcome: Primary: Number of Participants Who Had Hypotensive Events — 8; 21 Participants — p=0.01

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Methohexital (Drug); Propofol (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Milton S. Hershey Medical Center
Primary completion: Jan 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants Who Had Hypotensive Events	8; 21	0.01 sig
SECONDARY Number of Participants With Refractory Hypotension	2; 5	0.37
SECONDARY Duration of Each Hypotension Episode	5.1; 4.8	—
SECONDARY Systolic Blood Pressure	141; 126	—
SECONDARY Diastolic Blood Pressure	85; 72	—
SECONDARY Heart Rate	80; 76	—
SECONDARY Serum Concentration of Norepinephrine (NE) (at Baseline (Time 0) and 3,5,10 and 15 Min After Anesthetic Induction)	205.68; 200.59; 175.24; 166.04; 212.34; 208.93	0.277
SECONDARY Blood Levels of Epinephrine (at Baseline (Time 0) and 3,5,10 and 15 Min After Induction of Anesthesia)	70.89; 66.46; 60.86; 49.87; 89.85; 57.29	—
SECONDARY Blood Levels of Angiotensin II (AII) (at Baseline (Time 0) and 3,5,10 and 15 Min After Anesthetic Induction)	21.71; 18.85; 19.07; 19.56; 21.42; 20.62	—
SECONDARY Blood Levels of Arginine Vasopressin (AVP) (at Baseline (Time 0) and 3,5,10 and 15 Min After Anesthetic Induction) for Participants Who Did Not Receive AVP for Refractory Hypotension	30.75; 29.76; 25.07; 26.50; 34.66; 23.99	—
SECONDARY Blood Levels of AVP (at Baseline (Time 0) and 3,5,10 and 15 Min) for Participants Who Received AVP for Refractory Hypotension	14.85; 33.28; 10.57; 30.24; 13.73; 29.89	—

Summary

Patient undergoing general anesthesia in elective surgery will be assigned to receive either methohexital or propofol general anesthesia. Hypotensive events during the first 15 minutes of induction will be compared between the groups to ascertain which drug is less likely to cause a hypotensive event.

Eligibility Criteria

Inclusion Criteria

treated for at least 6 weeks with ACEIs or ARB
undergoing elective surgery under general endotracheal anesthesia
ASA Physical Class I or II

Exclusion Criteria

BMI >45kg/m^2
taking both ACEI and ARB
history of difficult intubation in the past
require rapid sequence induction and intubation
uncontrolled baseline blood pressure (SBP>180mmHg or DBP >110 mmHg) at anesthesia preoperative clinic visit
contraindication to the use of propofol or methohexital
significant coronary artery disease
history of systolic heart failure
history of renal failure (creatine level >2 mg/dL)

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Data sourced from ClinicalTrials.gov (NCT02624050). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.