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Home › Conditions › Hypotension

Hypotension

Subtypes of Hypotension

Orthostatic hypotension 1

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hypotension

35 trials tracked for Hypotension: 10 in phase 3 or 4 and 5 with published results. The most-cited published study has 61 citations.

35Trials tracked
10Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 6 Phase 3 4 Phase 2 5 Other / NA 20
  1. Phase 4 Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI) Completed · 61 cited
  2. Phase 3 Midodrine for the Treatment of Refractory Hypotension Completed · 38 cited
  3. Phase 4 Norepinephrine vs Phenylephrine During General Anesthesia Completed · 34 cited
  4. Phase 3 Treatment of Post-SCI Hypotension Completed · 7 cited
  5. Phase 3 Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia Completed · 5 cited
  6. Phase 4 Oxytocin And Uterotonic Agent Use For Cesarean Delivery Completed
Show 29 more trials
  1. Phase 4 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed
  2. Phase 4 Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury Completed
  3. Phase 4 Spinal Anesthesia Induced Hypotension During Cesarean Section Completed
  4. Phase 3 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed
  5. Phase 2 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis Completed
  6. Phase 2 The Prevention of Hypotension After Epidural Analgesia After Major Surgery Completed
  7. Phase 2 A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis Completed
  8. Phase 2 Dose-response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the Operating Room Completed
  9. Phase 2 Efficacy Study of a Facemask Device to Treat Hypotension Completed
  10. N/A Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension Completed
  11. N/A Accuracy of Non-invasive Non-oscillometric Blood Pressure Wristband Completed
  12. N/A Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness Completed
  13. N/A Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock Completed
  14. N/A Decision Support for Intraoperative Low Blood Pressure Completed
  15. N/A Validation of Noninvasive Blood Pressure Device Completed
  16. N/A Enhancing the Cardiovascular Safety of Hemodialysis Care (Dialysafe) Completed
  17. N/A Comparison of Nasal and Forehead Oximetry in Critically Ill Patients at Risk for Decreased Peripheral Perfusion Completed
  18. N/A Study of Dopamine Versus Vasopressin for Treatment of Low Blood Pressure in Low Birth Weight Infants Completed
  19. N/A Use of Capnography in EGD and Colonoscopy With Moderate Sedation. Completed
  20. N/A Leg Elevation to Prevent Hypotension During Labor Completed
  21. N/A RAAS and Arterial Stiffness in SCI Completed
  22. N/A Fluid Responsiveness Evaluation in Sepsis-associated Hypotension Completed
  23. N/A Optimal VAsopressor titraTION Pilot Randomized Controlled Trial Completed
  24. N/A A Comparative Clinical Trial of the TensorTip, a Novel Non Invasive Device for Measurement Blood Parameters Completed
  25. N/A MediBeat - HeartBeat Observation Trial Completed
  26. N/A Outcomes After Hypotensive Neuraxial Anesthesia in Total Hip Arthroplasty Completed
  27. N/A Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs Completed
  28. N/A Phenylephrine in Spinal Anesthesia in Preeclamptic Patients Completed
  29. N/A Pre-epidural Sequential Compression Devices (SCDs) to Prevent Hypotension During Labor Completed

Showing the 35 most-cited and recently-updated of 35 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Hypotension: what the trials found

Several pharmacological interventions have been evaluated for the management of hypotension. Norepinephrine was studied in a large cohort where outcomes included 30-day mortality and rehospitalization rates 3. Phenylephrine was evaluated both as a bolus 2 and as an infusion, with the latter associated with specific APGAR scores 7.

Other established pharmacological interventions include Midodrine 8, Midodrine Hydrochloride 9, Oxytocin infusion 6, Northera 4, and N-Nitro L-arginine-methylester (L-NAME) 11. Additionally, hyperbaric bupivacaine was associated with specific newborn Apgar scores 10.

Fluid management and other interventions include the use of Plasmalyte 3ml/kg/hr, which showed no statistically significant difference in the development of renal injury (p=0.31) 5.

Recent results — preliminary, needs further review

  • Patient Activation was associated with specific dialysis adherence metrics 1.
  • The ClearSight HPI Monitoring system was evaluated regarding total time spent in hypotension (MAP <65 mmHg) and total intravenous fluid volume 17.
  • Leg Elevation was investigated as a management strategy 18.

For the clinician treating this condition

  • Multiple pharmacological agents, including Norepinephrine, Phenylephrine, Midodrine, and Oxytocin, are established interventions for managing hypotension.
  • Plasmalyte 3ml/kg/hr did not show a statistically significant impact on renal injury rates in the studied population.
  • Recent studies have explored non-pharmacological and monitoring interventions such as Patient Activation, Leg Elevation, and specialized monitoring systems.

AI synthesis of 13 cited trials, updated Jun 20, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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A new brain stimulation system could stop dangerous blood pressure crashes that cause Parkinson's patients to faint when standing up.
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Normal saline preservation solution increases serum sodium and blood pressure versus half saline in critically ill pediatric patients
Pediatrics RCT
Normal saline preservation solution increases serum sodium and blood pressure versus half saline in critically ill pediatric patients Study in critically ill children compares two IV fluid types for sodium and blood pressure effects
A double-blind RCT of 88 critically ill pediatric patients in a PICU compared normal saline (0.9% sodium chloride) to half saline (0.45% sod…
Normal saline raises sodium and blood pressure more than half saline in critically ill children, guiding safer fluid choices for recovery.
NEJM Apr 6, 2026
Higher baseline chondroitin sulfate predicts greater mortality benefit from restrictive fluid strategy in sepsis
Emergency Medicine RCT
Higher baseline chondroitin sulfate predicts greater mortality benefit from restrictive fluid strategy in sepsis Blood marker may help predict which sepsis patients benefit from less fluid
A biomarker analysis within an RCT of 574 patients with sepsis-associated hypotension found that higher baseline plasma chondroitin sulfate …
A blood marker may help doctors decide which sepsis patients benefit most from receiving less intravenous fluid during treatment.
Apr 2, 2026