N/A
N=25
Effects of a Resistance Training Program in Older Women With Sarcopenia
Sarcopenia
Bottom Line
View on ClinicalTrials.gov: NCT02628145 ↗Enrolled (actual)
25
Serious AEs
0.0%
Results posted
Oct 2023
Primary outcome: Primary: Muscle Mass Change: From Dual Energy X-ray Absorptiometry and Bioelectrical Impedance Analsysis - Appendicular Lean Mass (ALM in kg) Divided by Height (Meters-squared) — 0.09; 0.10 kg/m2 — p=0.91
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Resistance Training Intervention (Behavioral); Active Control Group (Behavioral)
- Age
- Older Adult · 65+ yrs
- Sex
- Female
- Sponsor
- University of Rhode Island
- Primary completion
- Jun 2016
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Muscle Mass Change: From Dual Energy X-ray Absorptiometry and Bioelectrical Impedance Analsysis - Appendicular Lean Mass (ALM in kg) Divided by Height (Meters-squared) |
0.09; 0.10 | 0.91 |
| SECONDARY Sarcopenia Status Change |
7; 5; 3; 3; 0; 0 | 0.88 |
| SECONDARY Balance Ability: Single-leg Stand. Scored Yes or No |
5; 4; 3; 4; 3; 2 | 0.068 |
| SECONDARY Mobility Change: 8 Foot Timed up and go From a Seated Position Around a Cone Back to a Seated Position |
-0.48; -0.74 | 0.48 |
| SECONDARY Hip Bone Mineral Density: Measured by Dual Energy X-ray Absorptiometry |
-0.0005; 0.0105 | 0.52 |
| SECONDARY Physical Functioning Change: Normal Gait Speed Time From 400-meter Walk |
-14.28; -20.23; -18.95; -20.89; -14.61; -23.68 | >0.05 |
| SECONDARY Grip Strength Change: From Hand Grip Dynamometry in kg |
1.08; 1.45; 1.67; 0.50; 0.25; -0.10 | >0.05 |
| SECONDARY Muscle Strength Change: Leg Press One-repetition Maximum in kg |
13.35; 10.95; 20.85; 17.93; 15.1; 12.50 | >0.05 |
| SECONDARY Chair Stand Time Change: Time to Complete Five Chair Rises From a Normal Chair |
-0.95; -1.05; -1.56; -2.39; -1.13; -2.70 | >0.05 |
| SECONDARY Chair Stand Ability: Ability to Rise From a Chair One Time - Yes or No |
12; 10; 0; 0 | — |
Summary
This is a randomized clinical trial with a control group that will test how periodized resistance training will impact measures of sarcopenia in older women who have been identified as presarcopenic or sarcopenic. The intervention will be approximately 12 weeks in duration with 24 total free-living older women. Outcome measures will be collected at baseline, 6 weeks and post-intervention.
Eligibility Criteria
Inclusion Criteria
- Women, aged 65-84 years;
- Low lean mass and/or low physical functioning based on current guidelines;
- Currently (≥ 6 months) not engaged in a regular exercise program;
- Post-menopausal by self-report.
Exclusion Criteria
- Failure to provide informed consent;
- Significant or suspected cognitive impairment;
- Severe hearing loss, speech disorder, language barrier or visual impairment;
- Progressive, degenerative neurologic disease;
- Terminal illness with life expectancy of 3 weeks, lipid lowering medications for > 6 months;
- Major joint, vascular, abdominal, or thoracic surgery within six months;
- Significant cardiovascular disease or implanted pacemaker/defibrillator;
- Inability to safely engage in mild to moderate exercise with muscular exertion.
Data sourced from ClinicalTrials.gov (NCT02628145). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.