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Home › Conditions › Sarcopenia

Sarcopenia

28 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sarcopenia

47 trials tracked for Sarcopenia: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 73 citations.

47Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 3 Phase 2 11 Phase 1 3 Other / NA 29
  1. Phase 3 Starting a Testosterone and Exercise Program After Hip Injury Completed · 73 cited
  2. Phase 3 Effect Of Ophiochepalus Striatus Extract On Serum IGF-1 And IL-6 Levels In Elderly Patients With Sarcopenia Completed · 3 cited
  3. Phase 4 Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men Completed
  4. Phase 3 Carnitine Supplementation and Skeletal Muscle Function Completed
  5. Phase 2 The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity Completed
  6. Phase 2 Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial. Completed
Show 41 more trials
  1. Phase 2 Biological Effects of Weight Loss In Older, Obese Women Completed
  2. Phase 2 Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease Completed
  3. Phase 2 A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study Completed
  4. Phase 2 Dose Range Finding Study of Bimagrumab in Sarcopenia Completed
  5. Phase 2 A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005) Completed
  6. Phase 2 A Study of Muscle Strength Maintenance in Older Adults Completed
  7. Phase 2 A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT) Completed
  8. Phase 2 Trial of Oral Glutamine on Mitochondrial Function in CKD Completed
  9. Phase 2 5-Alpha Reductase and Anabolic Effects of Testosterone Completed
  10. Phase 1 Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals Completed
  11. Phase 1 Effect of a Ghrelin Receptor Agonist on Muscle and Bone Completed
  12. Phase 1 Ankle Assistance and Resistance in Older Adults Completed
  13. N/A The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia Completed
  14. N/A Effect of an EAA/Whey Composition on Protein Metabolism Completed
  15. N/A Omega-3 Supplementation and Resistance Training Completed
  16. N/A The Efficacy of Aerobic Exercise Training on ANS and Endothelial Function in Compensated Cirrhosis Completed
  17. N/A Prognostic Value of Sarcopenia and Nutritional Status in Early-stage Non-small Cell Lung Cancer Completed
  18. N/A Study of the Long-term Effects of Exercise on Heath Indicators in Older People Completed
  19. N/A Blood Flow, Muscle Regeneration and Sarcopenia Completed
  20. N/A Effect of Fermented Milk Containing Lactobacillus Casei Strain Shirota in Sarcopenia Elderly Completed
  21. N/A Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults Completed
  22. N/A Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health Completed
  23. N/A Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults Completed
  24. N/A A Physical Activity Program in End-state Liver Disease Completed
  25. N/A Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults Completed
  26. N/A The Urinary Incontinence Treatment Study Completed
  27. N/A VR-based Rehabilitation in the Treatment and Prevention of Sarcopenia of Older Residents Completed
  28. N/A Time Course Adaptations Using Deuterated Creatine (D3Cr) Method Completed
  29. N/A Semi-Recumbent Vibration Therapy in Older Adults Completed
  30. N/A Integrated Physical Training With Protein Diet in Older Adults With Sarcopenia Symptoms. Completed
  31. N/A Identifying Therapeutic Targets of Accelerated Sarcopenia Completed
  32. N/A IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial Completed
  33. N/A Nutritional Biomarkers of Sarcopenia Completed
  34. N/A Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training Completed
  35. N/A Dietary Nitrate and Muscle Power With Aging Completed
  36. N/A Muscle Capillarization and Sarcopenia Completed
  37. N/A The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy. Completed
  38. N/A Effects of a Resistance Training Program in Older Women With Sarcopenia Completed
  39. N/A Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics Completed
  40. N/A FrAilty Care and wEll-funcTion in Community Dwelling Older Adults Completed
  41. N/A Bingocize: A Novel Mobile Application for Older Adult Health Completed

Showing the 47 most-cited and recently-updated of 47 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Sarcopenia prediction models in China show variable discriminative ability and limited clinical applicability
Rheumatology Sys. Review
Sarcopenia prediction models in China show variable discriminative ability and limited clinical applicability Experts reviewed many tools to predict muscle loss in older Chinese adults
This scoping review examines 20 articles encompassing 34 prediction models for sarcopenia in older adults in China. The prevalence ranged fr…
A review of twenty articles found many different ways to guess if older people in China have low muscle mass. Most tools used age, weight, a…
Frontiers Jun 4, 2026
Meta-analysis finds no significant association between statin use and sarcopenia in older adults
Geriatrics & Aging Meta-analysis
Meta-analysis finds no significant association between statin use and sarcopenia in older adults Large review finds no clear link between statin use and muscle loss in older adults
A systematic review and meta-analysis of 9,080 older adults from European and Asian populations found no statistically significant associati…
A large review of over 9,000 older adults found no clear link between taking statins and losing muscle mass or strength.
Jun 4, 2026
Combined aerobic and resistance training significantly improves FEV1, FVC, and MIP in older sarcopenic patients
Geriatrics & Aging Meta-analysis
Combined aerobic and resistance training significantly improves FEV1, FVC, and MIP in older sarcopenic patients Combined exercise training improves lung function in older adults with muscle loss
This systematic review and meta-analysis of 655 older patients with sarcopenia found that combined aerobic and resistance training significa…
Older adults with muscle loss gain better lung function when doing both aerobic and resistance training together, not just one type.
Jun 1, 2026
Narrative review links protein quality and exercise to sarcopenia management in older adults
Nutrition & Obesity Medicine Sys. Review
Narrative review links protein quality and exercise to sarcopenia management in older adults The protein trick that keeps muscles strong as you age
This narrative review examines protein intake, amino acid composition, and physical activity for sarcopenia prevention in older adults. The …
For older adults, the usual protein advice falls short: you need more protein, spread across the day, with a special amino acid called leuci…
Frontiers May 13, 2026
Meta-analysis of digital health interventions for frailty and sarcopenia in older adults
Geriatrics & Aging Meta-analysis
Meta-analysis of digital health interventions for frailty and sarcopenia in older adults Digital health tools help older adults with frailty improve muscle mass and walking speed in recent studies
This meta-analysis of 16 studies evaluated digital health interventions for older adults with frailty and sarcopenia. It found significant i…
Digital health programs helped older adults with frailty gain muscle mass and walk faster. Balance and daily life quality also got better, t…
May 12, 2026
Meta-analysis finds obstructive sleep apnea associated with sarcopenia in adults
ENT (Otolaryngology) Meta-analysis
Meta-analysis finds obstructive sleep apnea associated with sarcopenia in adults Sleep apnea linked to higher muscle loss risk in many adult groups studied
This meta-analysis of 13,331 participants found a significant association between obstructive sleep apnea syndrome and sarcopenia. The assoc…
A large review of 13,331 adults found that sleep apnea is connected to losing muscle mass. The link is especially strong in older people and…
Frontiers May 9, 2026
Acupuncture combined with Baduanjin improves muscle mass and function in older adults with sarcopenia
Geriatrics & Aging RCT
Acupuncture combined with Baduanjin improves muscle mass and function in older adults with sarcopenia Combination therapy improves muscle mass in older adults with sarcopenia
This randomized controlled trial enrolled 105 adults aged 60 to 84 years with sarcopenia at Nanjing Hospital of Traditional Chinese Medicine…
A 12-week trial found that combining acupuncture with Baduanjin exercise improved muscle mass and physical function more than either treatme…
May 1, 2026
Meta-analysis shows exercise interventions impact TNF-alpha but not IL-6 or CRP in older adults
Allergy & Immunology Meta-analysis
Meta-analysis shows exercise interventions impact TNF-alpha but not IL-6 or CRP in older adults Exercise may lower specific inflammation markers in older adults
This meta-analysis of randomized controlled trials evaluated the effect of exercise interventions on serum inflammatory biomarker levels in …
New evidence shows that exercise interventions can significantly reduce certain inflammatory markers in older adults facing frailty or sarco…
Frontiers Apr 30, 2026
Sarcopenia in older patients with sepsis is associated with specific plasma metabolomic changes
Rheumatology Cohort
Sarcopenia in older patients with sepsis is associated with specific plasma metabolomic changes Metabolic changes link muscle loss to sepsis in older adults
In this prospective observational cohort study of 84 older patients with sepsis, researchers identified significant differences in plasma me…
New findings show how specific chemical changes in the blood connect muscle wasting to severe infections in older patients.
Frontiers Apr 30, 2026
Standard physical examination indicators predict sarcopenia risk with high accuracy in a health checkup population
Primary Care & Family Medicine Cohort
Standard physical examination indicators predict sarcopenia risk with high accuracy in a health checkup population New Tool Predicts Muscle Loss Years in Advance
This retrospective cohort study evaluated 3,277 participants from routine health exams to assess the discriminative performance of standard …
A free online tool uses basic health data to predict muscle loss years before symptoms appear—giving people a real chance to act early.
Frontiers Apr 28, 2026
Narrative review discusses sarcopenia and intramuscular vaccination immune landscape gaps
Hematology Sys. Review
Narrative review discusses sarcopenia and intramuscular vaccination immune landscape gaps Understanding muscle immunity helps improve vaccines for people with sarcopenia
This narrative review examines the intersection of sarcopenia and intramuscular vaccination.
We still do not fully understand how muscle immunity changes in health and disease, which makes it hard to predict vaccine responses in peop…
Frontiers Apr 23, 2026
Narrative review links ultra-processed foods to sarcopenia and functional impairment in adults globally
Nutrition & Obesity Medicine Sys. Review
Narrative review links ultra-processed foods to sarcopenia and functional impairment in adults globally Why Your Food Choices Could Be Aging You Prematurely
This narrative review examines the association between ultra-processed foods (UPF) intake and adverse health outcomes in adults.
Eating too many ultra-processed foods speeds up biological aging and weakens muscles, making daily tasks harder for adults.
Frontiers Apr 21, 2026

Questions about Sarcopenia

Can standard physical exam indicators accurately predict my sarcopenia risk?

Yes, standard physical exam indicators like calf circumference, BMI, and handgrip strength can predict sarcopenia risk with good accuracy, especially when combined in a validated model.

Full answer →
Does exercise lower TNF-alpha levels in older adults with sarcopenia?

Yes, exercise can lower TNF-alpha levels in older adults with sarcopenia, based on multiple clinical trials and meta-analyses.

Full answer →
Do specific plasma metabolites change in older patients with sepsis and sarcopenia?

Yes, older patients with sepsis and sarcopenia show distinct plasma metabolomic changes, including altered amino acid, lipid, and steroid pathways, compared to those without sarcopenia.

Full answer →
Does obstructive sleep apnea increase my risk of developing sarcopenia?

Yes, research suggests obstructive sleep apnea (OSA) is linked to a higher risk of sarcopenia, with meta-analyses showing about 85% increased odds, though the exact mechanisms are still being studied.

Full answer →

All Sarcopenia Articles