Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Sarcopenia

Sarcopenia

34 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sarcopenia

47 trials tracked for Sarcopenia: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 75 citations.

47Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 3 Phase 2 11 Phase 1 3 Other / NA 29
  1. Phase 3 Starting a Testosterone and Exercise Program After Hip Injury Completed · 75 cited
  2. Phase 3 Effect Of Ophiochepalus Striatus Extract On Serum IGF-1 And IL-6 Levels In Elderly Patients With Sarcopenia Completed · 3 cited
  3. Phase 4 Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men Completed
  4. Phase 3 Carnitine Supplementation and Skeletal Muscle Function Completed
  5. Phase 2 The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity Completed
  6. Phase 2 Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial. Completed
Show 41 more trials
  1. Phase 2 Biological Effects of Weight Loss In Older, Obese Women Completed
  2. Phase 2 Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease Completed
  3. Phase 2 A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study Completed
  4. Phase 2 Dose Range Finding Study of Bimagrumab in Sarcopenia Completed
  5. Phase 2 A Study of the Safety and Efficacy of MK-0773 in Women With Sarcopenia (Loss of Muscle Mass)(MK-0773-005) Completed
  6. Phase 2 A Study of Muscle Strength Maintenance in Older Adults Completed
  7. Phase 2 A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT) Completed
  8. Phase 2 Trial of Oral Glutamine on Mitochondrial Function in CKD Completed
  9. Phase 2 5-Alpha Reductase and Anabolic Effects of Testosterone Completed
  10. Phase 1 Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals Completed
  11. Phase 1 Effect of a Ghrelin Receptor Agonist on Muscle and Bone Completed
  12. Phase 1 Ankle Assistance and Resistance in Older Adults Completed
  13. N/A The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia Completed
  14. N/A Effect of an EAA/Whey Composition on Protein Metabolism Completed
  15. N/A Omega-3 Supplementation and Resistance Training Completed
  16. N/A The Efficacy of Aerobic Exercise Training on ANS and Endothelial Function in Compensated Cirrhosis Completed
  17. N/A Prognostic Value of Sarcopenia and Nutritional Status in Early-stage Non-small Cell Lung Cancer Completed
  18. N/A Study of the Long-term Effects of Exercise on Heath Indicators in Older People Completed
  19. N/A Blood Flow, Muscle Regeneration and Sarcopenia Completed
  20. N/A Effect of Fermented Milk Containing Lactobacillus Casei Strain Shirota in Sarcopenia Elderly Completed
  21. N/A Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults Completed
  22. N/A Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health Completed
  23. N/A Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults Completed
  24. N/A A Physical Activity Program in End-state Liver Disease Completed
  25. N/A Effect of Potassium Bicarbonate Supplementation on Bone and Muscle in Older Adults Completed
  26. N/A The Urinary Incontinence Treatment Study Completed
  27. N/A VR-based Rehabilitation in the Treatment and Prevention of Sarcopenia of Older Residents Completed
  28. N/A Time Course Adaptations Using Deuterated Creatine (D3Cr) Method Completed
  29. N/A Semi-Recumbent Vibration Therapy in Older Adults Completed
  30. N/A Integrated Physical Training With Protein Diet in Older Adults With Sarcopenia Symptoms. Completed
  31. N/A Identifying Therapeutic Targets of Accelerated Sarcopenia Completed
  32. N/A IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial Completed
  33. N/A Nutritional Biomarkers of Sarcopenia Completed
  34. N/A Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training Completed
  35. N/A Dietary Nitrate and Muscle Power With Aging Completed
  36. N/A Muscle Capillarization and Sarcopenia Completed
  37. N/A The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy. Completed
  38. N/A Effects of a Resistance Training Program in Older Women With Sarcopenia Completed
  39. N/A Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics Completed
  40. N/A FrAilty Care and wEll-funcTion in Community Dwelling Older Adults Completed
  41. N/A Bingocize: A Novel Mobile Application for Older Adult Health Completed

Showing the 47 most-cited and recently-updated of 47 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sarcopenia: what the trials found

Testosterone administration was evaluated for its impact on muscle mass and physical performance in patients with sarcopenia; however, no statistically significant changes were observed in 6-minute walk distance (p=0.853), total lean body mass (p=0.336), or appendicular lean body mass (p=0.934) 5. In a separate study, testosterone injection was associated with a reduction in global fatigue scores as measured by the Brief Fatigue Inventory 4.

Bimagrumab was evaluated across two trials for its effects on physical performance; neither trial showed significant improvements in Short Physical Performance Battery (SPPB) scores [12, 13] or 6-minute walk test (6MWT) distances [12, 13]. Additionally, bimagrumab did not significantly alter usual gait speed over 4 meters 13.

Recent results — preliminary, needs further review

  • * Yakult 300 LIGHT Fermented Milk was associated with significant improvements in sarcopenia markers, specifically handgrip strength (p=0.05) and walk speed (p=0.05), alongside changes in gut microbiota (p<0.05) 3. * Resistance exercise training showed statistically significant results regarding leg lean mass (p<0.01) and knee extension strength (p<0.01) 22. * Aerobic exercise combined with a nutrition consultant did not produce significant changes in time-domain or frequency-domain heart rate variability parameters 2. * Ankle resistance and biofeedback were investigated as an intervention 19. * Progressive resistance training was evaluated for sarcopenia management 1.

For the clinician treating this condition

  • Testosterone therapy did not demonstrate significant improvements in lean body mass or walking distance in clinical trials 5.
  • Bimagrumab did not result in statistically significant improvements in gait speed or 6-minute walk distances [12, 13].
  • Fermented milk (Yakult 300 LIGHT) showed potential for improving handgrip strength and walking speed in patients with sarcopenia 3.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Circadian misalignment associated with increased risk of osteoporosis, sarcopenia, and osteoarthritis
Nutrition & Obesity Medicine Sys. Review
Circadian misalignment associated with increased risk of osteoporosis, sarcopenia, and osteoarthritis Circadian Disruption Linked to Bone and Muscle Loss
This narrative review examines the impact of circadian disruption on musculoskeletal health, specifically regarding bone loss, muscle protei…
Shift work and irregular eating may harm bones and muscles. A new review explains how.
Frontiers Jun 22, 2026
Digital health technologies offer varying levels of clinical readiness for managing sarcopenia in hemodialysis patients
Nutrition & Obesity Medicine Sys. Review
Digital health technologies offer varying levels of clinical readiness for managing sarcopenia in hemodialysis patients Digital tools may help manage muscle loss in dialysis patients
This narrative review examines the role of digital health tools like wearables and mobile apps in monitoring sarcopenia among patients on ma…
New research explores how wearable devices and mobile apps can track muscle loss and improve daily life for people on dialysis.
Frontiers Jun 19, 2026
Diverse exercise modalities mitigate systemic and local inflammation in older adults with sarcopenia
Rheumatology Sys. Review
Diverse exercise modalities mitigate systemic and local inflammation in older adults with sarcopenia Different Exercise Types May Reduce Inflammation in Muscle Loss
This narrative review examines how aerobic, resistance, and high-intensity interval training impact inflammatory markers in older adults wit…
Specific types of exercise, from aerobic to high-intensity training, may help manage inflammation linked to muscle loss in older adults.
Frontiers Jun 8, 2026
NAD+ repletion via NMN or NR shows context-dependent effects on muscle stem cell homeostasis and sarcopenia
Nutrition & Obesity Medicine Sys. Review
NAD+ repletion via NMN or NR shows context-dependent effects on muscle stem cell homeostasis and sarcopenia NAD+ boosters may help muscle stem cells fight aging weakness
This systematic review synthesizes nearly 60 representative preclinical and clinical studies on NAD+ repletion for sarcopenia. The authors d…
A review of nearly 60 studies suggests NAD+ precursors like NMN or NR could support muscle stem cells and reduce oxidative stress in sarcope…
Frontiers Jun 5, 2026
Sarcopenia prediction models in China show variable discriminative ability and limited clinical applicability
Rheumatology Sys. Review
Sarcopenia prediction models in China show variable discriminative ability and limited clinical applicability Experts reviewed many tools to predict muscle loss in older Chinese adults
This scoping review examines 20 articles encompassing 34 prediction models for sarcopenia in older adults in China. The prevalence ranged fr…
A review of twenty articles found many different ways to guess if older people in China have low muscle mass. Most tools used age, weight, a…
Frontiers Jun 4, 2026
Meta-analysis finds no significant association between statin use and sarcopenia in older adults
Geriatrics & Aging Meta-analysis
Meta-analysis finds no significant association between statin use and sarcopenia in older adults Large review finds no clear link between statin use and muscle loss in older adults
A systematic review and meta-analysis of 9,080 older adults from European and Asian populations found no statistically significant associati…
A large review of over 9,000 older adults found no clear link between taking statins and losing muscle mass or strength.
Jun 4, 2026
Sarcopenia Significantly Increases Mortality Risk And Hospital Readmission Rates Among Patients With Diabetes In This Large Meta-Analysis
Diabetes & Endocrinology Meta-analysis
Sarcopenia Significantly Increases Mortality Risk And Hospital Readmission Rates Among Patients With Diabetes In This Large Meta-Analysis Sarcopenia raises death and heart risk in diabetes
A massive meta-analysis of 471,986 patients reveals sarcopenia drastically raises mortality and cardiovascular risks in diabetes. Clinicians…
For people with diabetes, losing muscle mass significantly boosts the risk of dying, heart disease, and being readmitted to the hospital.
Jun 1, 2026
Combined aerobic and resistance training significantly improves FEV1, FVC, and MIP in older sarcopenic patients
Geriatrics & Aging Meta-analysis
Combined aerobic and resistance training significantly improves FEV1, FVC, and MIP in older sarcopenic patients Combined exercise training improves lung function in older adults with muscle loss
This systematic review and meta-analysis of 655 older patients with sarcopenia found that combined aerobic and resistance training significa…
Older adults with muscle loss gain better lung function when doing both aerobic and resistance training together, not just one type.
Jun 1, 2026
Whey protein, vitamin D, and epicatechin show strongest effects on sarcopenia outcomes in network meta-analysis
Geriatrics & Aging Meta-analysis
Whey protein, vitamin D, and epicatechin show strongest effects on sarcopenia outcomes in network meta-analysis Whey protein and Vitamin D help older adults with muscle loss
This systematic review and network meta-analysis of anti-inflammatory diets and supplements in elderly patients with sarcopenia found whey p…
A large review found that whey protein, Vitamin D, and specific supplements can improve strength and speed in older adults with muscle loss.
Jun 1, 2026
Narrative review links protein quality and exercise to sarcopenia management in older adults
Nutrition & Obesity Medicine Sys. Review
Narrative review links protein quality and exercise to sarcopenia management in older adults The protein trick that keeps muscles strong as you age
This narrative review examines protein intake, amino acid composition, and physical activity for sarcopenia prevention in older adults. The …
For older adults, the usual protein advice falls short: you need more protein, spread across the day, with a special amino acid called leuci…
Frontiers May 13, 2026
Meta-analysis of digital health interventions for frailty and sarcopenia in older adults
Geriatrics & Aging Meta-analysis
Meta-analysis of digital health interventions for frailty and sarcopenia in older adults Digital health tools help older adults with frailty improve muscle mass and walking speed in recent studies
This meta-analysis of 16 studies evaluated digital health interventions for older adults with frailty and sarcopenia. It found significant i…
Digital health programs helped older adults with frailty gain muscle mass and walk faster. Balance and daily life quality also got better, t…
May 12, 2026
Meta-analysis finds obstructive sleep apnea associated with sarcopenia in adults
ENT (Otolaryngology) Meta-analysis
Meta-analysis finds obstructive sleep apnea associated with sarcopenia in adults Sleep apnea linked to higher muscle loss risk in many adult groups studied
This meta-analysis of 13,331 participants found a significant association between obstructive sleep apnea syndrome and sarcopenia. The assoc…
A large review of 13,331 adults found that sleep apnea is connected to losing muscle mass. The link is especially strong in older people and…
Frontiers May 9, 2026

Questions about Sarcopenia

Can standard physical exam indicators accurately predict my sarcopenia risk?

Yes, standard physical exam indicators like calf circumference, BMI, and handgrip strength can predict sarcopenia risk with good accuracy, especially when combined in a validated model.

Full answer →
Does exercise lower TNF-alpha levels in older adults with sarcopenia?

Yes, exercise can lower TNF-alpha levels in older adults with sarcopenia, based on multiple clinical trials and meta-analyses.

Full answer →
Do specific plasma metabolites change in older patients with sepsis and sarcopenia?

Yes, older patients with sepsis and sarcopenia show distinct plasma metabolomic changes, including altered amino acid, lipid, and steroid pathways, compared to those without sarcopenia.

Full answer →
Does obstructive sleep apnea increase my risk of developing sarcopenia?

Yes, research suggests obstructive sleep apnea (OSA) is linked to a higher risk of sarcopenia, with meta-analyses showing about 85% increased odds, though the exact mechanisms are still being studied.

Full answer →

All Sarcopenia Articles