Phase 2
N=51
Motivated Behavior in Adults With and Without ADHD
ADHD
Bottom Line
View on ClinicalTrials.gov: NCT02630017 ↗Enrolled (actual)
51
Serious AEs
0.0%
Results posted
Aug 2021
Primary outcome: Primary: Number of High-effort Selections in the Effort-based Decision Making Task — 16.4; 21.35; 20.45; 19.8 Number of high-effort selections
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- ADHD methylphenidate first, placebo second (Drug); ADHD placebo first, methylphenidate second (Drug); Non-ADHD methylphenidate first, placebo second (Drug); Non-ADHD placebo first, methylphenidate second (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Arkansas
- Primary completion
- Sep 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of High-effort Selections in the Effort-based Decision Making Task |
16.4; 21.35; 20.45; 19.8 | — |
Summary
To investigate the effects of methylphenidate on motivated behavior in adults with and without ADHD
Eligibility Criteria
Inclusion Criteria
- generally healthy
- between the ages of 18-45
- non-ADHD subjects do not meet criteria for ADHD diagnosis or any subtype as determined by the Conners Diagnostic Interview or any T-Score > 55 on Inattentive Symptoms, Hyperactive-Impulsive Symptoms, Total Symptoms or ADHD Index subscales of the CAARS.
- ADHD subjects meet criteria for a primary diagnosis of ADHD, any subtype, based on DSM-5
Exclusion Criteria
- inability to attend all required experimental sessions
- significant health problems (e.g., current and uncontrolled liver, lung, or heart problems, current or past seizure disorder, serious head trauma)
- primary diagnosis of Axis I psychiatric disorders other than ADHD (e.g., depression, anxiety disorder, schizophrenia)
- meet DSM-5 criteria for substance use disorder other than nicotine in the past 12 months
- use of psychoactive medications in the past 6 months as indicated by self-report
- positive urine drug screen for drugs or positive breath alcohol concentration
- contraindications for MPH
- among women, nursing or a positive pregnancy test
- IQ 40 years of age and has blood pressure over 130/80 or heart rate over 88 beats per minute)
- body mass ratio > 30
Data sourced from ClinicalTrials.gov (NCT02630017). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.