N/A Completed N=141 Randomized Treatment

Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock

Cardiac Arrest

Source: ClinicalTrials.gov NCT02633358 ↗

Enrolled (actual)

141

Serious AEs

71.6%

Results posted

Jul 2019

Primary outcomePrimary: Survival Rate - Number of Participants Alive — 55; 20; 32; 34 Participants — p=<0.001

Summary

Acute myocardial infarction complicated with cardiogenic shock trigger IL-6, the strong inflammatory response, result in multiple organ failure, even death. While therapeutic hypothermia,to expect the possibility of anti-inflammatory effect via IL-6 bi-phasic effect and IL-10 , to improve the multiple organ failure, to increase survival rate and well cerebral performance.

Outcome Measures

Outcome	Result	p-value
PRIMARY Survival Rate - Number of Participants Alive	55; 20; 32; 34	<0.001 sig
SECONDARY Neurologic Outcome - Number of Participants	30; 10; 57; 44	0.04 sig

Eligibility Criteria

Inclusion Criteria

Age between 18-100 years
Cardiogenic sock including initial lactate level >18 mg/dL, necessary of vasopressor to keep mean artery pressure >65mmHg after adequate fluid supply, and signs of reduced cardiac output including disturbance consciousness, cold limbs, decreased urine output, acute pulmonary congestion and so on.

Exclusion Criteria

Patient or family refuse
Metastatic cancer
Pregnancy

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Data sourced from ClinicalTrials.gov (NCT02633358). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.