Phase 4 N=100 Randomized Triple-blind Prevention

Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery

Neuromuscular Blockade · Postoperative Complications

Bottom Line

View on ClinicalTrials.gov: NCT02635542 ↗

Enrolled (actual)

100

Serious AEs

0.0%

Results posted

Jul 2018

Primary outcome: Primary: Number of Participants With Postoperative Pulmonary Complications — 8; 8 Participants — p=1.00

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: Succinylcholine (Drug); Cisatracurium (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Chicago
Primary completion: Sep 2017

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants With Postoperative Pulmonary Complications	8; 8	1.00
SECONDARY Surgical Conditions	4.96; 4.65	0.02 sig

Summary

The investigators will conduct a prospective, randomized trial to assess the impact of neuromuscular blockade on early (<72 hours post-ICU admission) postoperative respiratory complications in cardiac surgical patients. The study will compare continual neuromuscular blockade with cisatracurium to a single dose of succinylcholine during general anesthesia for cardiac surgery.

Eligibility Criteria

Inclusion Criteria

Elective cardiac surgery (CABG, valve replacement, CABG + valve) requiring cardiopulmonary bypass

Exclusion Criteria

Emergency surgery
Extremes of age
Previous cardiac surgery
Clinical contraindications to succinylcholine or cisatracurium
Anticipated difficult tracheal intubation
Preoperative mechanical ventilation
Preoperative pharmacologic/mechanical hemodynamic support

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02635542). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.