Phase 4
Completed N=100
Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery
Neuromuscular Blockade · Postoperative Complications
Source: ClinicalTrials.gov NCT02635542 ↗
Enrolled (actual)
100
Serious AEs
0.0%
Results posted
Jul 2018
Primary outcomePrimary: Number of Participants With Postoperative Pulmonary Complications — 8; 8 Participants — p=1.00
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The investigators will conduct a prospective, randomized trial to assess the impact of neuromuscular blockade on early (<72 hours post-ICU admission) postoperative respiratory complications in cardiac surgical patients. The study will compare continual neuromuscular blockade with cisatracurium to a single dose of succinylcholine during general anesthesia for cardiac surgery.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Postoperative Pulmonary Complications |
8; 8 | 1.00 |
| SECONDARY Surgical Conditions |
4.96; 4.65 | 0.02 sig |
Eligibility Criteria
Inclusion Criteria
- Elective cardiac surgery (CABG, valve replacement, CABG + valve) requiring cardiopulmonary bypass
Exclusion Criteria
- Emergency surgery
- Extremes of age
- Previous cardiac surgery
- Clinical contraindications to succinylcholine or cisatracurium
- Anticipated difficult tracheal intubation
- Preoperative mechanical ventilation
- Preoperative pharmacologic/mechanical hemodynamic support
Data sourced from ClinicalTrials.gov (NCT02635542). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.