Phase 4
Completed N=54
The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine
Source: ClinicalTrials.gov NCT02657031 ↗Enrolled (actual)
54
Serious AEs
0.0%
Results posted
Dec 2017
Primary outcomePrimary: Headache Following Intervention — 63.5; 43.5 mm
◆ Published Evidence
Highly cited
558citations · ~31 / year
National Hospital Ambulatory Medical Care Survey: 2006 emergency department summary.
Summary
This study compares the efficacy of low dose Ketamine versus Compazine for the control of headache in patients presenting to the Emergency Department.
Linked Publications (5)
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National Hospital Ambulatory Medical Care Survey: 2006 emergency department summary.
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A Neurologist's Guide to Acute Migraine Therapy in the Emergency Room.
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A prospective, randomized trial of intravenous prochlorperazine versus subcutaneous sumatriptan in acute migraine therapy in the emergency department.
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Prospective, randomised, double blind, controlled comparison of metoclopramide and pethidine in the emergency treatment of acute primary vascular and tension type headache episodes.
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A randomized trial of intravenous ketorolac versus intravenous metoclopramide plus diphenhydramine for tension-type and all nonmigraine, noncluster recurrent headaches.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Headache Following Intervention |
63.5; 43.5 | — |
| SECONDARY Anxiety |
33.7; 21.2 | — |
| SECONDARY Nausea |
38.9; 22.9 | — |
| SECONDARY The Number of Participants Experiencing Vomiting |
2; 3 | — |
| SECONDARY The Number of Patients Experiencing Restlessness |
3; 3 | — |
Eligibility Criteria
Inclusion Criteria
- Age 18 to 65 years
- Temperature < 100.4° F
- Diastolic Blood Pressure <104 mm Hg
- Normal neurological exam and mormal mental status
Exclusion Criteria
- Pregnant or breastfeeding.
- Meningeal signs are present
- Acute angle closure glaucoma is suspected.
- Head trauma within the previous two weeks
- Lumbar puncture within the previous two weeks
- Thunderclap onset of the headache
- Weight more than 150 kg or less than 40 kg.
- Known allergy to one of the study drugs.
- History of schizophrenia or bipolar disorder.
- History of intracranial hypertension.
- Is a prisoner
- Patient declined informed consent
- Non-English speaking patient.
- Attending provider excludes patient
Data sourced from ClinicalTrials.gov (NCT02657031) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.